Evidence map›Paper›PMID 41224414›Full record

ReviewSurgical pathology clinics2025

High-Risk Breast Lesions on Core Biopsy: Rates of Upgrade and Management Recommendations.

Anne Grabenstetter

Abstract readReview
In one paragraph

Review in Surgical pathology clinics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Anne GrabenstetterDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: grabensa@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

High-risk lesions of the breast confer an increased risk for breast cancer. Due to wide variations in the reported rate of upgrade to carcinoma at excision, optimal management of these lesions is controversial. Intraductal papillomas, mucocele-like lesions, radial scars, and complex sclerosing lesions without atypia found on core biopsy do not require excision. Flat epithelial atypia and classic lobular neoplasia can be managed conservatively while nonclassic forms of lobular carcinoma in situ should undergo excision. In most cases, atypical ductal hyperplasia should be surgically excised, though there is a subset of patients for whom nonsurgical management can be considered.

Indexed as

BreastBreast NeoplasmsPrecancerous ConditionsBiopsy, Large-Core NeedleCarcinoma, Intraductal, NoninfiltratingFemaleHumansPapilloma, IntraductalAtypiaBiopsyBreast cancerHigh-riskUncertain malignant potentialUpgrade

Identifiers

PMID41224414
PMCPMC13537485

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.