Evidence map›Paper›PMID 41224353›Full record

ReviewEndocrine journal2026

Diagnostic criteria for acquired hypothalamic obesity - international expert guidance document.

Hermann L Müller, Tomohiro Tanaka, Tomonobu Hasegawa, Tsuyoshi Isojima, Jun Mori, Masamichi Kurosaki, Hiroshi Nishioka, Hyung Jin Choi, A Ram Hong, Ja Hye Kim and 1 more

Abstract readReview
In one paragraph

Review in Endocrine journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hermann L MüllerDepartment of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Carl von Ossietzky Universität, Klinikum Oldenburg AöR, Oldenburg, Germany.ORCID http://orcid.org/0000-0003-4929-9966
Tomohiro TanakaDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.ORCID http://orcid.org/0000-0002-6212-4274
Tomonobu HasegawaDepartment of Pediatrics, Keio University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0143-3989
Tsuyoshi IsojimaDepartment of Pediatrics, Toranomon Hospital, Tokyo, Japan.ORCID http://orcid.org/0000-0003-0011-0325
Jun MoriDivision of Pediatric Endocrinology, Metabolism and Nephrology, Children's Medical Center, Osaka City General Hospital, Osaka, Japan.ORCID http://orcid.org/0000-0002-1271-1577
Masamichi KurosakiDivision of Neurosurgery, Department of Brain and Neurosciences, Faculty of Medicine Tottori University, Tottori, Japan.ORCID http://orcid.org/0009-0000-3695-0479
Hiroshi NishiokaDepartment of Hypothalamic and Pituitary Surgery, Toranomon Hospital, Tokyo, Japan.
Hyung Jin ChoiDepartment of Brain and Cognitive Sciences, Department of Anatomy and Cell Biology, Seoul National University, Seoul, Republic of Korea.
A Ram HongDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0002-2494-9902
Ja Hye KimDepartment of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-2477-5199
Hiroshi ArimaDepartment of Endocrinology and Diabetes, Tokai National Higher Education and Research System, Nagoya University, Nagoya, Japan.ORCID http://orcid.org/0000-0003-3746-1997

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acquired hypothalamic obesity (aHO) presents as rapid, clinically relevant, and persistent weight gain due to hypothalamic damage, and leads to significant morbidity/mortality and decreased quality of life. Causes include craniopharyngioma and other space-occupying lesions, neurosurgical intervention, irradiation, and traumatic brain injury. This review summarizes the evidence and provides expert opinion on diagnostic criteria for aHO. Eight experts in neuroendocrinology and neurosurgery from Japan and Europe participated in a multidisciplinary meeting at the 57

Indexed as

Hypothalamic DiseasesObesityConsensusHumansHypothalamusMagnetic Resonance ImagingCraniopharyngiomaHypothalamic obesityHypothalamusObesityQuality of lifeSequelae

Identifiers

PMID41224353
PMCPMC12895118

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.