Evidence map›Paper›PMID 41224350›Full record

SynthesisSaudi medical journal2025

Long-term growth hormone effects in Prader-Willi syndrome: A systematic review and meta-analysis.

Mahmoud N Almutadares, Nour M Gazzaz, Naseem Y Alyahyawi, Nuha M Alrayes, Eman A Mazi, Fahad F Mansouri, Kholoud A Hothan, Hanaa A Hamadallah, Esraa M Bukhari, Ahlam A Mazi

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mahmoud N AlmutadaresFrom the Department of Genetic Medicine (Almutadares), Faculty of Medicine, King Abdulaziz University; from the Department of Pediatrics (Gazzaz, Alyahyawi, Hothan, Bukhari, A. Mazi), Faculty of Medicine, King Abdulaziz University; from the Medical Laboratory Sciences (Alrayes), Faculty of Applied Medical Sciences, King Abdulaziz University; from Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (Alrayes); from the Primary Health Care (E. Mazi), King Abdullah Complex Center, Jeddah Second Health Cluster, Ministry of Health; from the Department of Emergency Medicine (Mansouri), Faculty of Medicine, King Abdulaziz University; and from the Faculty of Medicine in Rabigh (Hamadallah), King Abdulaziz University Jeddah, Kingdom of Saudi Arabia.
Nour M GazzazFrom the Department of Genetic Medicine (Almutadares), Faculty of Medicine, King Abdulaziz University; from the Department of Pediatrics (Gazzaz, Alyahyawi, Hothan, Bukhari, A. Mazi), Faculty of Medicine, King Abdulaziz University; from the Medical Laboratory Sciences (Alrayes), Faculty of Applied Medical Sciences, King Abdulaziz University; from Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (Alrayes); from the Primary Health Care (E. Mazi), King Abdullah Complex Center, Jeddah Second Health Cluster, Ministry of Health; from the Department of Emergency Medicine (Mansouri), Faculty of Medicine, King Abdulaziz University; and from the Faculty of Medicine in Rabigh (Hamadallah), King Abdulaziz University Jeddah, Kingdom of Saudi Arabia.
Naseem Y AlyahyawiFrom the Department of Genetic Medicine (Almutadares), Faculty of Medicine, King Abdulaziz University; from the Department of Pediatrics (Gazzaz, Alyahyawi, Hothan, Bukhari, A. Mazi), Faculty of Medicine, King Abdulaziz University; from the Medical Laboratory Sciences (Alrayes), Faculty of Applied Medical Sciences, King Abdulaziz University; from Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (Alrayes); from the Primary Health Care (E. Mazi), King Abdullah Complex Center, Jeddah Second Health Cluster, Ministry of Health; from the Department of Emergency Medicine (Mansouri), Faculty of Medicine, King Abdulaziz University; and from the Faculty of Medicine in Rabigh (Hamadallah), King Abdulaziz University Jeddah, Kingdom of Saudi Arabia.
Nuha M AlrayesFrom the Department of Genetic Medicine (Almutadares), Faculty of Medicine, King Abdulaziz University; from the Department of Pediatrics (Gazzaz, Alyahyawi, Hothan, Bukhari, A. Mazi), Faculty of Medicine, King Abdulaziz University; from the Medical Laboratory Sciences (Alrayes), Faculty of Applied Medical Sciences, King Abdulaziz University; from Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (Alrayes); from the Primary Health Care (E. Mazi), King Abdullah Complex Center, Jeddah Second Health Cluster, Ministry of Health; from the Department of Emergency Medicine (Mansouri), Faculty of Medicine, King Abdulaziz University; and from the Faculty of Medicine in Rabigh (Hamadallah), King Abdulaziz University Jeddah, Kingdom of Saudi Arabia.
Eman A MaziFrom the Department of Genetic Medicine (Almutadares), Faculty of Medicine, King Abdulaziz University; from the Department of Pediatrics (Gazzaz, Alyahyawi, Hothan, Bukhari, A. Mazi), Faculty of Medicine, King Abdulaziz University; from the Medical Laboratory Sciences (Alrayes), Faculty of Applied Medical Sciences, King Abdulaziz University; from Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (Alrayes); from the Primary Health Care (E. Mazi), King Abdullah Complex Center, Jeddah Second Health Cluster, Ministry of Health; from the Department of Emergency Medicine (Mansouri), Faculty of Medicine, King Abdulaziz University; and from the Faculty of Medicine in Rabigh (Hamadallah), King Abdulaziz University Jeddah, Kingdom of Saudi Arabia.
Fahad F MansouriFrom the Department of Genetic Medicine (Almutadares), Faculty of Medicine, King Abdulaziz University; from the Department of Pediatrics (Gazzaz, Alyahyawi, Hothan, Bukhari, A. Mazi), Faculty of Medicine, King Abdulaziz University; from the Medical Laboratory Sciences (Alrayes), Faculty of Applied Medical Sciences, King Abdulaziz University; from Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (Alrayes); from the Primary Health Care (E. Mazi), King Abdullah Complex Center, Jeddah Second Health Cluster, Ministry of Health; from the Department of Emergency Medicine (Mansouri), Faculty of Medicine, King Abdulaziz University; and from the Faculty of Medicine in Rabigh (Hamadallah), King Abdulaziz University Jeddah, Kingdom of Saudi Arabia.
Kholoud A HothanFrom the Department of Genetic Medicine (Almutadares), Faculty of Medicine, King Abdulaziz University; from the Department of Pediatrics (Gazzaz, Alyahyawi, Hothan, Bukhari, A. Mazi), Faculty of Medicine, King Abdulaziz University; from the Medical Laboratory Sciences (Alrayes), Faculty of Applied Medical Sciences, King Abdulaziz University; from Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (Alrayes); from the Primary Health Care (E. Mazi), King Abdullah Complex Center, Jeddah Second Health Cluster, Ministry of Health; from the Department of Emergency Medicine (Mansouri), Faculty of Medicine, King Abdulaziz University; and from the Faculty of Medicine in Rabigh (Hamadallah), King Abdulaziz University Jeddah, Kingdom of Saudi Arabia.
Hanaa A HamadallahFrom the Department of Genetic Medicine (Almutadares), Faculty of Medicine, King Abdulaziz University; from the Department of Pediatrics (Gazzaz, Alyahyawi, Hothan, Bukhari, A. Mazi), Faculty of Medicine, King Abdulaziz University; from the Medical Laboratory Sciences (Alrayes), Faculty of Applied Medical Sciences, King Abdulaziz University; from Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (Alrayes); from the Primary Health Care (E. Mazi), King Abdullah Complex Center, Jeddah Second Health Cluster, Ministry of Health; from the Department of Emergency Medicine (Mansouri), Faculty of Medicine, King Abdulaziz University; and from the Faculty of Medicine in Rabigh (Hamadallah), King Abdulaziz University Jeddah, Kingdom of Saudi Arabia.
Esraa M BukhariFrom the Department of Genetic Medicine (Almutadares), Faculty of Medicine, King Abdulaziz University; from the Department of Pediatrics (Gazzaz, Alyahyawi, Hothan, Bukhari, A. Mazi), Faculty of Medicine, King Abdulaziz University; from the Medical Laboratory Sciences (Alrayes), Faculty of Applied Medical Sciences, King Abdulaziz University; from Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (Alrayes); from the Primary Health Care (E. Mazi), King Abdullah Complex Center, Jeddah Second Health Cluster, Ministry of Health; from the Department of Emergency Medicine (Mansouri), Faculty of Medicine, King Abdulaziz University; and from the Faculty of Medicine in Rabigh (Hamadallah), King Abdulaziz University Jeddah, Kingdom of Saudi Arabia.
Ahlam A MaziFrom the Department of Genetic Medicine (Almutadares), Faculty of Medicine, King Abdulaziz University; from the Department of Pediatrics (Gazzaz, Alyahyawi, Hothan, Bukhari, A. Mazi), Faculty of Medicine, King Abdulaziz University; from the Medical Laboratory Sciences (Alrayes), Faculty of Applied Medical Sciences, King Abdulaziz University; from Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (Alrayes); from the Primary Health Care (E. Mazi), King Abdullah Complex Center, Jeddah Second Health Cluster, Ministry of Health; from the Department of Emergency Medicine (Mansouri), Faculty of Medicine, King Abdulaziz University; and from the Faculty of Medicine in Rabigh (Hamadallah), King Abdulaziz University Jeddah, Kingdom of Saudi Arabia.ORCID https://orcid.org/0000-0003-3125-5260

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the long-term effects and mortality rates associated with GH therapy in patients with Prader-Willi Syndrome (PWS). Prader-Willi Syndrome is a rare genetic disease characterized by growth hormone (GH) deficiency among other endocrine disorders.

methodsA systematic literature search was carried out on 4 databases including PubMed, Scopus, Web of Science, and Cochrane databases. The search was based on two keywords: "Growth hormone" AND "Prader-Willi Syndrome". Outcome data included height-standard deviation score (SDS), weight SDS, body mass index (BMI)-SDS, insulin like growth factor 1 (IGF1), mortality, low density lipoprotein (LDL)-cholesterol, and blood glucose.

resultsA total of 41 studies were included, of which 30 were involved in the meta-analysis. Following treatment with GH, height-SDS showed a significant increase compared to baseline in two timeline subgroups (≤2 years and >2 years), with a mean difference (MD) of 1.05 (95% CI: 0.92-1.18,

conclusionGH therapy in PWS significantly improves height and IGF-1 SDS, while relatively decreasing BMI compared to no-GH, indicative of lean mass growth and healthy development. Nonetheless, GH therapy requires careful metabolic monitoring due to its mixed effects on cholesterol and glucose levels.

Indexed as

Human Growth HormonePrader-Willi SyndromeBlood GlucoseBody HeightBody Mass IndexCholesterol, LDLHumansInsulin-Like Growth Factor IBlood GlucoseCholesterol, LDLHuman Growth HormoneInsulin-Like Growth Factor IGrowth hormonelong-termmortalityPrader-Willi syndrome

Identifiers

PMID41224350
PMCPMC12625669

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