Evidence map›Paper›PMID 41224332›Full record

Observational studySaudi medical journal2025

Cytopathological evaluation of serous effusions using the ISRSFC system: Risk of malignancy and demographic associations in a Saudi cohort.

Magdi M Salih, Shatha Abdullah Alotaibi, Ashwag Mohammed Al Talhi, Manal Ali Hassan, Khwaimsa Mohammad Bhaket, Nesreen Ahmad Bakhsh

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Magdi M SalihFrom the Department of Clinical Laboratory Sciences (Salih), College of Applied Medical Sciences, Taif University; from the Laboratory Medical Science (Alotaibi, Al Talhi, Hassan, Bhaket), King Faisal Medical Complex; from the Pathology Department (Bakhsh), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.ORCID https://orcid.org/0000-0003-1827-3659
Shatha Abdullah AlotaibiFrom the Department of Clinical Laboratory Sciences (Salih), College of Applied Medical Sciences, Taif University; from the Laboratory Medical Science (Alotaibi, Al Talhi, Hassan, Bhaket), King Faisal Medical Complex; from the Pathology Department (Bakhsh), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
Ashwag Mohammed Al TalhiFrom the Department of Clinical Laboratory Sciences (Salih), College of Applied Medical Sciences, Taif University; from the Laboratory Medical Science (Alotaibi, Al Talhi, Hassan, Bhaket), King Faisal Medical Complex; from the Pathology Department (Bakhsh), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
Manal Ali HassanFrom the Department of Clinical Laboratory Sciences (Salih), College of Applied Medical Sciences, Taif University; from the Laboratory Medical Science (Alotaibi, Al Talhi, Hassan, Bhaket), King Faisal Medical Complex; from the Pathology Department (Bakhsh), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
Khwaimsa Mohammad BhaketFrom the Department of Clinical Laboratory Sciences (Salih), College of Applied Medical Sciences, Taif University; from the Laboratory Medical Science (Alotaibi, Al Talhi, Hassan, Bhaket), King Faisal Medical Complex; from the Pathology Department (Bakhsh), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
Nesreen Ahmad BakhshFrom the Department of Clinical Laboratory Sciences (Salih), College of Applied Medical Sciences, Taif University; from the Laboratory Medical Science (Alotaibi, Al Talhi, Hassan, Bhaket), King Faisal Medical Complex; from the Pathology Department (Bakhsh), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo classify serous effusions using the ISRSFC and assess malignancy risk across diagnostic categories, considering patient demographics and clinical features. Serous fluid cytopathology is a minimally invasive, cost-effective method for diagnosing benign and malignant conditions. The International System for Reporting Serous Fluid Cytopathology (ISRSFC) standardizes reporting, yet data from Saudi Arabia are limited.

methodsA prospective observational study was conducted from October 2023 to June 2024. Serous fluid samples (peritoneal, pleural, pericardial) were stained with the Papanicolaou method and evaluated microscopically.

resultsAmong 153 effusions, peritoneal (60.7%) was most common. Patients aged 41-66 comprised the largest group (41.2%). Cytologically, 36% were negative for malignancy, 19% atypia of undetermined significance (AUS), and 18.3% malignant. Risk of malignancy by ISRSFC category was: nondiagnostic (3.2%), negative for malignancy (5.4%), AUS (6.8%), suspicious for malignancy (52.7%), malignant (100%). Significant associations were found with clinical and demographic factors.

conclusionThe ISRSFC effectively classifies effusions and stratifies malignancy risk. Peritoneal effusion was most frequent, highlighting cytology's diagnostic value and the need for further regional studies.

Indexed as

Ascitic FluidCytodiagnosisNeoplasmsPericardial EffusionAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsSaudi ArabiaYoung Adultbody cavitiescytomorphologyeffusionISRSFCSaudi population

Identifiers

PMID41224332
PMCPMC12625665

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