Evidence map›Paper›PMID 41224310›Full record

ArticleBMJ open2025

Readiness Brain Operation Optimization Training (ReBOOT) protocol: a feasibility randomised controlled trial for a cognitive prehabilitation programme for epilepsy surgery conducted at Cleveland Clinic, USA.

Kayela Arrotta, Selma Babiker, Jeramiah Lake, Nicolas Thompson, Anthony Lioi, Imad Najm, Robyn M Busch

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05992402 (Readiness Brain Operation Optimization Training), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05992402 narecruitingnot on this map

Readiness Brain Operation Optimization Training (ReBOOT) for Epilepsy Surgery

TypeinterventionalSponsorKayela ArrottaRan2023 to 2028Enrolled64ConditionsEpilepsyArmsReBOOT program
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kayela ArrottaEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA arrottk@ccf.org.ORCID http://orcid.org/0000-0001-6482-4795
Selma BabikerEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Jeramiah LakeEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Nicolas ThompsonDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Anthony LioiEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Imad NajmEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Robyn M BuschEpilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRisk of cognitive decline following epilepsy surgery can be a significant barrier for patients pursuing surgery, and post-surgical cognitive changes can impact quality of life (QOL), surgical satisfaction and functional independence. Readiness Brain Operation Optimization Training (ReBOOT) is a virtual cognitive prehabilitation intervention that provides patients with psychoeducation and cognitive strategies prior to surgery to increase pre-surgical preparedness and post-surgical functional independence in the circumstance that a patient experiences cognitive decline after surgery. The primary aim of this feasibility trial is to evaluate the acceptability, adherence and procedural feasibility of implementing ReBOOT in patients being evaluated for epilepsy surgery. Secondary, explorative objectives include examining preliminary trends in QOL, compensatory strategy use, cognitive function and psychosocial outcomes to inform a future definitive trial. METHODS AND ANALYSIS: This is a single-centre, parallel-group, feasibility randomised controlled trial of a standardised cognitive prehabilitation programme for patients who are considering epilepsy surgery. Participants are randomly assigned to intervention (n=32) or control groups (n=32). The intervention group is enrolled in ReBOOT, a virtual programme that includes two 1-hour individual sessions and four 1-hour group sessions. Feasibility outcomes include attendance, homework adherence, attrition and participant satisfaction for participants randomised to the intervention group. Exploratory analyses will use longitudinal linear mixed-effects models to describe trends in exploratory outcomes over time. Data will be used to refine procedures and estimate parameters (eg, effect sizes and variance) for a future fully powered trial. ETHICS AND DISSEMINATION: Cleveland Clinic Institutional Review Board approved the study protocol, which is publicly available and registered on the National Institutes of Health ClinicalTrials.gov (NCT05992402) site. Results will be disseminated through conference presentations and academic publications, as well as shared with outside study sponsors (Society for Clinical Neuropsychology-Division 40 of the American Psychological Association; American Epilepsy Society). TRIAL REGISTRATION NUMBER: NCT05992402.

Indexed as

Cognitive DysfunctionEpilepsyPostoperative ComplicationsPreoperative CareAdultCognitionFeasibility StudiesFemaleHumansMaleQuality of LifeRandomized Controlled Trials as TopicCognitionEpilepsyNeurosurgery

Identifiers

PMID41224310
PMCPMC12612755

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.