Evidence map›Paper›PMID 41224274›Full record

ReviewInternal medicine (Tokyo, Japan)2026

Spinocerebellar Ataxia Type 3 Accompanied by Amyotrophic Lateral Sclerosis: A Case Report and Comprehensive Literature Review.

Masato Takubo, Yuki Matsumoto, Chihiro Sasaki, Kensuke Ikeda, Naoto Sugeno, Hitoshi Warita, Masashi Aoki

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Masato TakuboTohoku University School of Medicine, Japan.
Yuki MatsumotoDepartment of Neurology, Tohoku University Hospital, Japan.
Chihiro SasakiDepartment of Neurology, Tohoku University Hospital, Japan.
Kensuke IkedaDepartment of Neurology, Tohoku University Graduate School of Medicine, Japan.
Naoto SugenoDepartment of Neurology, Tohoku University Graduate School of Medicine, Japan.
Hitoshi WaritaDepartment of Neurology, Tohoku University Graduate School of Medicine, Japan.
Masashi AokiDepartment of Neurology, Tohoku University Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinocerebellar ataxia type 3 (SCA3) is a hereditary neurodegenerative disorder characterized by cerebellar ataxia, whereas amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease. We herein report a 62-year-old man with genetically confirmed SCA3 who subsequently developed rapidly progressive asymmetric muscle weakness, atrophy, and fasciculations. Clinical features, including preserved tendon reflexes and widespread denervation observed on electromyography, support the diagnosis of concomitant sporadic ALS. Our literature review revealed only a few similar cases, suggesting the under-recognition of this rare combination. This case underscores the importance of considering coexisting ALS in patients with SCA3 to enable a timely diagnosis and management.

Indexed as

Amyotrophic Lateral SclerosisMachado-Joseph DiseaseHumansMaleMiddle Agedamyotrophic lateral sclerosiscerebellar ataxiaMachado-Joseph diseasespinocerebellar ataxia type 3

Identifiers

PMID41224274
PMCPMC13423774

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.