ArticleThe Korean journal of internal medicine2025
Predictive value of the modified ROX index for extubation failure in mechanically ventilated patients.
Article in The Korean journal of internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
BACKGROUND/
aimsClinicians use several measures to determine whether patients will tolerate liberation from mechanical ventilation. This study aimed to evaluate the predictive value of the modified ROX index (mROX) for extubation failure. In addition, we sought to find its role in guiding personalized post-extubation non-invasive respiratory support.
methodsPatients who received mechanical ventilation and underwent planned extubation between May 2015 and December 2021 in medical intensive care unit were included. The primary outcome was extubation failure, defined as reintubation or death within seven days of extubation. The mROX, calculated as the ratio of partial arterial oxygen pressure to fraction of inspired oxygen (PaO2/FiO2) divided by the respiratory rate, was used to predict extubation failure.
resultsOf the 606 patients, 160 (26.4%) experienced extubation failure. An mROX value below 11.12 was identified as an independent predictor of extubation failure, with an area under the receiver operating characteristic curve of 0.743, demonstrating greater accuracy than traditional indices. The prophylactic application of non-invasive ventilation or high-flow nasal oxygen was associated with a lower risk of extubation failure in the moderate-risk group (11.12 ≤ mROX < 17.55), with an adjusted odds ratio of 0.43 (95% confidence interval, 0.20-0.91); however, this association was not significant in the high-risk (mROX < 11.12) or low-risk (mROX ≥ 17.55) groups.
conclusionThe mROX is a reliable and clinically useful method for predicting extubation failure. It facilitates improved stratification of extubation risk, allows for more tailored post-extubation non-invasive respiratory support, and may enhance clinical outcomes during the critical processes of ventilator liberation and extubation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.