Evidence map›Paper›PMID 41223847›Full record

Trial reportJournal of aging and physical activity2026

Exploratory Analysis of Mental Health and Quality of Life Outcomes in a Randomized Controlled Trial to Reduce Sitting Time in Older Adults With Obesity.

Stefani Florez-Acevedo, Mikael Anne Greenwood-Hickman, Weiwei Zhu, Andrea J Cook, Kristin Delaney, Beverly B Green, David E Arterburn, Jennifer B McClure, Dori E Rosenberg

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of aging and physical activity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03739762 (Randomized Trial to Reduce Sitting Time and Improve Cardiometabolic Health in Obese Older Adults), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03739762 nacompletednot on this map

Randomized Trial to Reduce Sitting Time and Improve Cardiometabolic Health in Obese Older Adults

TypeinterventionalSponsorKaiser PermanenteRan2019 to 2023Enrolled283ConditionsSedentary LifestyleArmsi-STAND, Healthy Living control
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stefani Florez-AcevedoDepartment of Health Systems and Population Health, University of Washington, School of Public Health, Seattle, WA, USA.ORCID 0000-0001-8148-5799
Mikael Anne Greenwood-HickmanKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.ORCID 0000-0002-7576-7762
Weiwei ZhuKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Andrea J CookKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.ORCID 0000-0002-6848-5222
Kristin DelaneyKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Beverly B GreenKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.ORCID 0000-0003-3040-3436
David E ArterburnKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.ORCID 0000-0002-5208-8492
Jennifer B McClureKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Dori E RosenbergKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.ORCID 0000-0003-1017-8833

Funding

Randomized Trial to Reduce Sitting Time and Improve Cardiometabolic Health in Obese Older AdultsR01HL132880 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI ROSENBERG, DORI E · 2018 to 2022
$3.3M
NHLBI NIH HHS R01 HL132880
6 · The paper itself

Abstract

backgroundBoth sedentary behavior and mental health issues are highly prevalent among older adults. Observational data indicate positive associations between high sedentary behavior and conditions like depression and anxiety. However, it is not known if reducing sedentary behavior leads to changes in mental health. PURPOSE: We conducted an exploratory analysis of a sedentary behavior reduction intervention's effect on self-reported mental health outcomes and quality of life in older adults with obesity.

methodsThe Health Aging Resources to Thrive trial (clinicaltrials.gov # NCT03739762) enrolled older adults aged 60-89 years with a body mass index of 30-50 kg/m2, who self-reported sitting >6 hr/day. Participants were randomized to a sedentary behavior reduction intervention or a healthy living attention-control group. The intervention included 10 behavioral coaching sessions, sitting reduction goals, a standing desk, and a fitness tracker. The attention-control group received 10 coaching contacts to set general healthy living goals excluding physical activity or sedentary behavior. Mental health and quality of life outcomes (depressive symptoms, anxiety symptoms, loneliness, quality of life, sleep disturbance, and pain interference) were measured at baseline, 3 months, and 6 months. We used linear regression models with generalized estimating equations to estimate adjusted mean changes from baseline for each outcome and mean change difference between groups.

resultsParticipants (N = 283, n = 140 intervention, n = 143 control; mean age = 68.8 years, 65.7% women, 68.9% White non-Hispanic, 55.5% retired) in the intervention group had significant reductions in perceived loneliness score compared with the control group at 6 months (-0.27; 95% confidence interval [-0.52, -0.02]). Depressive symptoms, pain, sleep disturbance, and quality of life improved in both the intervention and control groups, but differences between groups were not statistically significant at 3 or 6 months.

conclusionsSedentary behavior reduction may positively impact loneliness in older adults.

Indexed as

Mental HealthObesityQuality of LifeSedentary BehaviorSitting PositionAgedAged, 80 and overAnxietyDepressionExerciseFemaleHumansLonelinessMaleMiddle Agedanxietydepressive symptomslonelinessphysical activitysedentary behavior

Identifiers

PMID41223847
PMCPMC13599601

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.