ArticleJMIR research protocols2025
Effect of Obesity on Perioperative Outcomes Following Lung Cancer Surgery: Protocol for a Meta-Analysis and Systematic Review.
Article in JMIR research protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgical resection is the primary curative treatment for early-stage lung cancer-the leading global cause of cancer mortality, responsible for nearly 1 in 5 cancer deaths in 2022. Obesity is a global health concern that may influence surgical outcomes; yet, its impact on perioperative outcomes following lung cancer surgery remains controversial.
objectiveThis protocol outlines a meta-analysis and systematic review to evaluate the association between obesity and perioperative outcomes in patients who underwent a lung cancer resection.
methodsObservational studies related to patients with lung cancer who underwent surgical resection were searched in 5 English and 3 Chinese literature databases: PubMed, Embase, Cochrane Library, Web of Science, MEDLINE, Chinese National Knowledge Infrastructure, Wanfang, and the Chinese Biomedical Database. The search period for these 8 electronic databases was from inception to 2025. The PROSPERO database and the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) database were also searched. Qualified studies were screened and selected by 2 authors independently. The literature obtained were imported into NoteExpress to screen the titles and abstracts. After reading the full text of the remaining studies, the final number of studies were determined. Two reviewers independently extracted data from the included studies by using a predesigned data extraction tool. The Newcastle-Ottawa Scale was used to evaluate the quality of the research. The primary outcome of this study was to evaluate the postoperative mortality in people living with obesity undergoing lung cancer surgical procedures. The secondary outcomes were the postoperative complications, average length of stay, blood loss during the operation, and operation time in people living with obesity undergoing lung cancer surgical procedures. For dichotomous data, we plan to present results as risk ratios with 95% CIs. For continuous data, we will use mean difference with 95% CIs. The Review Manager software (version 5.4) will be used for the meta-analysis and statistical analysis. Sensitivity analysis and Egger test will be performed with Stata software (version 16.0).
resultsThe results are not yet accessible because this is a protocol for a systematic review and meta-analysis. The protocol is registered in PROSPERO under the registration number CRD42025648330. By August 26, 2025, we completed the literature search of the 8 databases and completed the selection and extraction of data.
conclusionsThis study will synthesize existing evidence to clarify whether obesity is a risk factor for adverse outcomes or if it confers a protective effect, as suggested by the obesity paradox. These findings will guide clinical decision-making and improve perioperative care for obese people with lung cancer.
trial registrationPROSPERO CRD42025648330; https://www.crd.york.ac.uk/PROSPERO/view/CRD42025648330. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/76315.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.