Evidence map›Paper›PMID 41223220›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The SWI/SNF chromatin-remodeling subunit DPF2 regulates macrophage inflammation in intestinal injury via the CACNA1D-mediated MAPK pathway.

Mintao Ji, Haisheng Liang, Shuai Dong, Yuhan Guo, Yiping Lin, Hong Zhang, Yuhong Wang, Zhe Lei, Xiaoya Xu, Yinyin Shu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mintao Ji *Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.ORCID 0000-0001-5492-5111
Haisheng Liang *Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.ORCID 0009-0008-2668-4048
Shuai Dong *State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Jiangsu Key Laboratory of Infection and Immunity, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou 215123, China.ORCID 0000-0003-2056-6549
Yuhan GuoState Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Jiangsu Key Laboratory of Infection and Immunity, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou 215123, China.
Yiping LinState Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Jiangsu Key Laboratory of Infection and Immunity, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou 215123, China.
Hong ZhangDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Yuhong WangDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Zhe LeiDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.ORCID 0000-0002-5220-7391
Xiaoya XuInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Yinyin ShuInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Zhisen ZhangState Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Jiangsu Key Laboratory of Infection and Immunity, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou 215123, China.ORCID 0000-0001-7865-765X
Xiaoni JinState Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Jiangsu Key Laboratory of Infection and Immunity, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou 215123, China.
Shuangshuang LuState Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Jiangsu Key Laboratory of Infection and Immunity, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou 215123, China.
Wensheng ZhangState Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Jiangsu Key Laboratory of Infection and Immunity, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou 215123, China.
Lingchuan GuoDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Chunlin ShaoInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.ORCID 0000-0001-9336-9912
Lei ChangInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China.ORCID 0000-0002-2288-1748

Funding

China Postdoctoral Science Foundation () 2023M742540 2024T170624Jiangsu Provincial Out-standing Postdoctoral Program 2023ZB254JST | Jiangsu Natural Science Foundation | Outstanding Youth Foundation of Jiangsu Province (Outstanding Youth Foundation of Jiangsu Province of China) BK20240039MOST | National Natural Science Foundation of China (NSFC) 12235004MOST | National Natural Science Foundation of China (NSFC) 82373525 82173465MOST | National Natural Science Foundation of China (NSFC) 82404206Shanghai Science and Technology Committee Project 24ZR1414300The Natural Science Foundation of Jiangsu Province for Youth BK20230490
6 · The paper itself

Abstract

The immune system plays a pivotal role in pathogenesis of intestinal injury and subsequent regenerative processes, particularly macrophages, orchestrate the inflammatory response and tissue repair. Here, we identified that loss of double PHD fingers 2 (DPF2) enhances intestinal regeneration and reduces inflammation. Using a combination of mouse genetics, single cell RNA sequencing, and spatial transcriptomics, we found that

Indexed as

Calcium Channels, L-TypeDNA-Binding ProteinsInflammatory Bowel DiseasesIntestinal MucosaMacrophagesTranscription FactorsAnimalsEnhancer Elements, GeneticHistone CodeHistonesHumansMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutCACNA1D protein, humanCacna1d protein, mouseCalcium Channels, L-TypeDNA-Binding ProteinsDPF2 protein, humanDPF2 protein, mouseHistonesTranscription FactorsCACNA1DcalciumDPF2intestinal inflammationmacrophage

Identifiers

PMID41223220
PMCPMC12646317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.