Evidence map›Paper›PMID 41223055›Full record

ArticleCell reports2025

Genetic and chromatin regulation of Pvt1 monoallelic expression.

Christy Luong, Mason Chen, Julia A Belk, Katerina Kraft, Anne-Valerie Gendrel, Edith Heard, Joanna Wysocka, Howard Y Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christy LuongDepartments of Dermatology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mason ChenDepartments of Dermatology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Julia A BelkDepartments of Dermatology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Katerina KraftDepartments of Dermatology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Anne-Valerie GendrelGulbenkian Institute for Molecular Medicine, 1649-028 Lisbon, Portugal.
Edith HeardEuropean Molecular Biology Laboratory, Director's Research, 69117 Heidelberg, Germany; Collège de France, 75005 Paris, France.
Joanna WysockaDepartment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Howard Y ChangDepartments of Dermatology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: howchang@stanford.edu.

Funding

LncRNA mechanisms in cancerR35CA209919 · NCI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2016 to 2022
$6.4M
NCI NIH HHS R35 CA209919
6 · The paper itself

Abstract

While most genes are equivalently expressed on both alleles, genes with random monoallelic expression (RME) stably maintain expression from only one allele, but the mechanisms and consequences of RME remain unclear. We performed allele-specific RNA sequencing (RNA-seq) on ∼100 F

Indexed as

AllelesChromatinGene Expression RegulationRNA, Long NoncodingAnimalsCell LineDNA MethylationHumansMiceNeural Stem CellsChromatinRNA, Long Noncodingallele-specific expressionchromatin stateCP: genomicsenhancer-promter interactionepigeneticgene regulationgenetichistone modificationslong non-coding RNAmonoallelic expressionMYCPvt1

Identifiers

PMID41223055
PMCPMC12832107

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.