Evidence map›Paper›PMID 41223026›Full record

ArticleJournal of the American Medical Informatics Association : JAMIA2026

PhenoFit: a framework for determining computable phenotyping algorithm fitness for purpose and reuse.

Laura K Wiley, Luke V Rasmussen, Rebecca T Levinson, Jennnifer Malinowski, Sheila M Manemann, Melissa P Wilson, Martin Chapman, Jennifer A Pacheco, Theresa L Walunas, Justin B Starren and 2 more

Abstract read
In one paragraph

Article in Journal of the American Medical Informatics Association : JAMIA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Laura K WileyDepartment of Neurology, Institute for Informatics, Data Science, and Biostatics, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, United States.ORCID 0000-0001-6681-9754
Luke V RasmussenDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.ORCID 0000-0002-4497-8049
Rebecca T LevinsonDepartment for General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, 69120, Germany.ORCID 0000-0002-2775-7543
Jennnifer MalinowskiWrite InScite LLC, Pound Ridge, NY 10576, United States.ORCID 0000-0001-7500-2199
Sheila M ManemannDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, United States.
Melissa P WilsonDivision of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.ORCID 0000-0001-9176-3131
Martin ChapmanDepartment of Population Health Sciences, King's College London, London, WC2R 2LS, United Kingdom.ORCID 0000-0002-5242-9701
Jennifer A PachecoCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.ORCID 0000-0001-8021-5818
Theresa L WalunasDivision of General Internal Medicine and Center for Health Information Partnerships, Department of Medicine, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.ORCID 0000-0002-7653-3650
Justin B StarrenCenter for Biomedical Informatics and Biostatistics, University of Arizona, Tucson, AZ 85721, United States.ORCID 0000-0002-5403-1115
Suzette J BielinskiDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, United States.ORCID 0000-0002-2905-5430
Rachel L RichessonDepartment of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI 48109, United States.ORCID 0000-0003-0279-7036

Funding

Michigan Institute for Clinical and Health Research (MICHR)UM1TR004404 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Julie C Lumeng · 2023 to 2026
$39.8M
NUCATS CTSA UM1 at Northwestern UniversityUM1TR005121 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Sara Becker, Richard D'Aquila · 2024 to 2026
$23.4M
Clinical Evidence Generation from Electronic Health Records for Precision MedicineK01LM013088 · NLM · UNIVERSITY OF COLORADO DENVER · PI WILEY, LAURA KATHERINE · 2019 to 2021
$533k
National Institutes of Health's National Center for Advancing Translational Sciences UM1TR004404-R.L.R.National Institutes of Health's National Center for Advancing Translational Sciences UM1TR005121-L.V.R.NCATS NIH HHS UM1 TR004404NCATS NIH HHS UM1TR004404NCATS NIH HHS UM1 TR005121NCATS NIH HHS UM1TR005121NIH HHSNLM NIH HHS K01 LM013088NLM NIH HHS K01LM013088NLM NIH HHS K01LM013088-L.K.W.
6 · The paper itself

Abstract

backgroundComputational phenotyping from electronic health records (EHRs) is essential for clinical research, decision support, and quality/population health assessment, but the proliferation of algorithms for the same conditions makes it difficult to identify which algorithm is most appropriate for reuse.

objectiveTo develop a framework for assessing phenotyping algorithm fitness for purpose and reuse. FITNESS FOR PURPOSE: Phenotyping algorithms are fit for purpose when they identify the intended population with performance characteristics appropriate for the intended application. FITNESS FOR REUSE: Phenotyping algorithms are fit for reuse when the algorithm is implementable and generalizable-that is, it identifies the same intended population with similar performance characteristics when applied to a new setting.

conclusionsThe PhenoFit framework provides a structured approach to evaluate and adapt phenotyping algorithms for new contexts increasing efficiency and consistency of identifying patient populations from EHRs.

Indexed as

AlgorithmsElectronic Health RecordsPhenotypeHumanscohort identificationcomputational phenotypingEHRfitness for purpose

Identifiers

PMID41223026
PMCPMC12844593

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.