ArticleJournal of natural medicines2026
Anti-inflammatory and UV-protective activities of isolated compounds from Calophyllum inophyllum L. in immune and skin cell models.
Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
High levels of UV radiation in Okinawa contribute to skin damage, photoaging, and inflammation. Calophyllum inophyllum L. (Tamanu) trees are frequently cultivated along roadways in Okinawa. The oil isolated from Tamanu nuts is renowned for antioxidants, antibacterial, and anti-inflammatory properties. However, the specific UV-absorbing compounds responsible for its anti-inflammatory activity remain unidentified. This study aimed to isolate, characterize, and evaluate the anti-inflammatory activity of UV-absorbing components from Okinawan Tamanu oil. Clinical tests confirmed the UV-protective effects of Tamanu oil, with SPF and PA values of 6.3 ± 0.4 and 2.9 ± 0.6, respectively. UV-absorbing compounds were isolated based on absorbance at 300 nm and structurally characterized by mass spectrometry and NMR. The anti-inflammatory effects of calophyllolide (CAL), inocalophyllin A (ICA), and inocalophyllin B (ICB) were evaluated in LPS-stimulated RAW 264 macrophages and UVB-induced HaCaT keratinocytes. The specific absorbance at 300 nm of CAL, ICA, and ICB isolated from Tamanu oil (300 nm specific absorbance
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