Evidence map›Paper›PMID 41222818›Full record

ArticleJournal of neurovirology2025

Progressive multifocal leukoencephalopathy in a young adult with DOCK8 deficiency: a case of JC virus reactivation in primary immunodeficiency.

Laura Naydovich, Joseph R Berger, Pavle S Milutinovic

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Laura NaydovichDepartment of Neurology, Division of Multiple Sclerosis, University of Pennsylvania, Philadelphia, PA, USA. laura.naydovich@pennmedicine.upenn.edu.
Joseph R BergerDepartment of Neurology, Division of Multiple Sclerosis, University of Pennsylvania, Philadelphia, PA, USA.
Pavle S MilutinovicDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive multifocal leukoencephalopathy (PML) is a rare, often fatal demyelinating disease of the central nervous system (CNS) caused by JC virus (JCV) reactivation in the setting of impaired cellular immunity. While commonly associated with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and immunosuppressive therapies, PML can also arise in primary immunodeficiency disorders. We report a case of PML in a young adult with autosomal recessive hyper-IgE syndrome (AR-HIES) due to DOCK8 deficiency, highlighting the importance of considering genetic immunodeficiencies in cases of JCV-PML without known iatrogenic or acquired causes.

Indexed as

Guanine Nucleotide Exchange FactorsJC VirusJob SyndromeLeukoencephalopathy, Progressive MultifocalVirus ActivationAdultHumansMaleYoung AdultDOCK8 protein, humanGuanine Nucleotide Exchange FactorsDOCK8 deficiencyHyper-IgE syndromeJC virus reactivationPrimary immunodeficiencyProgressive multifocal leukoencephalopathy

Identifiers

PMID41222818
PMCPMC12700977

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.