Evidence map›Paper›PMID 41222753›Full record

ArticleMolecular biology reports2025

Gene-Diet interaction between FTO rs9939609 and fiber intake in relation to GERD susceptibility.

Faezeh Tejareh, Fatemeh Sadat Fahimzad, Leila Dehghanian, Barbod Alhouei, Mahsa Vahdat, Maryam Shojaei, Mohammadtaghi Ghorbani Hesari, Mohammadreza Esfahanian, Saeid Doaei, Maryam Gholamalizadeh

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

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5 · Who and what money

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10 authors.

Faezeh TejarehDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Fatemeh Sadat FahimzadDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Leila DehghanianFaculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Barbod AlhoueiDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahsa VahdatDepartment of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Maryam ShojaeiCentral Research Laboratory, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammadtaghi Ghorbani HesariMashhad University of Medical Sciences, Mashhad, Iran.
Mohammadreza EsfahanianSchool of Medicine, Medical Faculty of Guilan Uiversity of Medical Sciences, Rasht, Iran.
Saeid DoaeiDepartment of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Doaei@gums.ac.ir.
Maryam GholamalizadehFaculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile the interaction between the fat mass and obesity-associated (FTO) gene and diet is known to influence health issues such as obesity, its effects on gastroesophageal reflux disease (GERD) risk remains unexplored. This study aimed to investigate the role of dietary intake of fibers in developing GERD in people with different FTO genotypes.

methodsThis case-control study was carried out on 450 participants aged 35-70 years, including 150 patients with GERD and 300 without GERD in Tehran, Iran. FTO genotyping was performed using tetra-primer amplification refractory mutation system-polymerase chain (ARMS-PCR) and dietary intake was assessed with a food frequency questionnaire (FFQ).

resultsGERD patients with the FTO rs9939609 TT genotype had a significantly higher intake of soluble fiber compared to the controls (P = 0.022). Among individuals with the TT genotype, higher soluble fiber intake was associated with an increased risk of GERD (OR = 1.410, 95% CI = 1.023-1.944) in a fully adjusted model.

conclusionsThe intake of soluble fiber is associated with the risk of GERD in carriers of the FTO rs9939609 TT genotype, suggesting a significant gene-diet interaction. However, further studies are warranted.

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTODietary FiberGastroesophageal RefluxAdultAgedCase-Control StudiesDietFemaleGenetic Predisposition to DiseaseGenotypeHumansIranMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsAlpha-Ketoglutarate-Dependent Dioxygenase FTODietary FiberFTO protein, humanDietary fiber intakeFTO geneGastroesophageal reflux disease (GERD)Polymorphism

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PMID41222753

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