Evidence map›Paper›PMID 41222711›Full record

ReviewJournal of neural transmission (Vienna, Austria : 1996)2026

Pesticides and parkinson's disease: causal relationship at the population and individual level?

Matthias Höllerhage

Abstract readReview
In one paragraph

Review in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Matthias HöllerhageDepartment of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. hoellerhage.matthias@mh-hannover.de.ORCID http://orcid.org/0000-0002-5333-0121

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pesticide exposure has been associated with an increased risk of Parkinson's disease (PD). As a result, PD has been recognized as an occupational disease among agricultural workers in France for over a decade. In March 2024, a similar recommendation for recognition was issued in Germany. Pesticides encompass a wide range of functional classes and chemical groups, making it challenging-evaluate their specific effects. Numerous epidemiological studies, including cohort and case-control studies, have investigated the association between pesticide exposure and PD risk. While some report statistically significant associations, others yield inconclusive results, partly due-the inherent difficulties in accurately quantifying pesticide exposure and overlap in the use of different pesticides. In addition, a large body of experimental research has examined the neurotoxicity of various pesticides on dopaminergic neurons using both in vitro and in vivo models of PD. This review summarizes the findings from epidemiological and experimental studies and discusses the current evidence linking pesticide exposure-risk for Parkinson's disease.

Indexed as

Occupational ExposureParkinson DiseaseParkinson Disease, SecondaryPesticidesAnimalsHumansPesticidesEpidemiological studiesOccupational diseaseParkinson’s diseasePesticides

Identifiers

PMID41222711
PMCPMC12855454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.