Evidence map›Paper›PMID 41222660›Full record

Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Early prediction of macular neovascularization phenotypes and prognostic evolution.

Serena Fragiotta, Mariacristina Parravano, Eliana Costanzo, Daniele De Geronimo, Monica Varano, Enrico Borrelli, Costanza Barresi, Riccardo Sacconi, Giuseppe Querques

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Serena FragiottaOphthalmology Unit, Department NESMOS, S. Andrea Hospital, University of Rome La Sapienza, Rome, 00189, Italy.ORCID http://orcid.org/0000-0002-6214-6270
Mariacristina ParravanoIRCCS-Fondazione Bietti, Via Livenza 3, Rome, 00198, Italy. mcparravano@gmail.com.ORCID http://orcid.org/0000-0002-2223-7311
Eliana CostanzoIRCCS-Fondazione Bietti, Via Livenza 3, Rome, 00198, Italy.ORCID http://orcid.org/0000-0002-9916-8895
Daniele De GeronimoIRCCS-Fondazione Bietti, Via Livenza 3, Rome, 00198, Italy.ORCID http://orcid.org/0000-0003-3242-8020
Monica VaranoIRCCS-Fondazione Bietti, Via Livenza 3, Rome, 00198, Italy.ORCID http://orcid.org/0000-0002-6530-1563
Enrico BorrelliDepartment of Surgical Sciences, University of Turin, Turin, Italy.ORCID http://orcid.org/0000-0003-2815-5031
Costanza BarresiDepartment of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy.ORCID http://orcid.org/0000-0003-4828-7170
Riccardo SacconiDepartment of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy.ORCID http://orcid.org/0000-0003-2891-2012
Giuseppe QuerquesDepartment of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute, Milan, Italy.ORCID http://orcid.org/0000-0002-3292-9581

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate baseline predictors of macular neovascularization (MNV) phenotypes and prognostic outcomes, including changes in visual acuity (VA) and the development of macular atrophy (MA) and fibrosis.

methodsA retrospective, observational, cohort study was performed on a total of 102 eyes from 97 patients with intermediate age-related macular degeneration (AMD) converting to MNV subtypes. Baseline features, including age, drusen, reticular pseudodrusen (RPD), subfoveal choroidal thickness (SFCT), and central retinal thickness (CRT), were analyzed. Predictive models that considered the baseline characteristics predicting the different MNV subtypes and prognostic outcomes were developed using Cox regression and generalized linear models.

resultsOf the included eyes, 68.6% developed type 1 MNV, 15.7% type 2 MNV, and 15.7% type 3 MNV. SFCT was a significant predictor of type 2 MNV, with thicker choroid predisposing to the lesion development (HR: 1.02, CI95%: 1, 1.03, p = 0.001). Age was the primary predictor for type 3 MNV (HR: 1.1, CI 95%: 1, 1.2, p = 0.02). Type 2 MNV exhibited the highest rate of fibrosis at follow-up (71.4%), compared to both type 1 (43.5%) and type 3 MNV (26.7%) (p = 0.04). Age at baseline and best-corrected visual acuity (BCVA) were factors associated with final vision loss (p < 0.001), while the presence of drusen alone appeared protective (p = 0.03). SFCT at baseline also reduced the risk of outer retinal atrophy (p = 0.01).

conclusionsSFCT served as a key indicator for type 2 MNV while aging predominantly predicted type 3 MNV. The findings may improve the early identification and tailored management of MNV phenotypes, optimizing visual outcomes and mitigating complications such as fibrosis and atrophy.

Indexed as

Fluorescein AngiographyMacula LuteaTomography, Optical CoherenceVisual AcuityWet Macular DegenerationAgedAged, 80 and overAngiogenesis InhibitorsChoroidDisease ProgressionFemaleFollow-Up StudiesFundus OculiHumansMaleMiddle AgedAngiogenesis InhibitorsAge-related macular degenerationDrusen: reticular pseudodrusenMacular atrophyMacular neovascularization

Identifiers

PMID41222660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.