Evidence map›Paper›PMID 41222636›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Characterizing the safety and efficacy of injection pharyngoplasty as a treatment for velopharyngeal insufficiency in adults.

Arjan Kalra, Laurence Gascon, William S Tierney, Ian Griffiths, Rebecca C Nelson, Paul C Bryson

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Arjan KalraCleveland Clinic Lerner College of Medicine, EC-10 Cleveland Clinic, 9501 Euclid Ave, Cleveland, OH, 44195, USA. kalraa4@ccf.org.ORCID http://orcid.org/0000-0002-4811-2541
Laurence GasconCleveland Clinic Voice Center, Head and Neck Institute, 9500 Euclid Ave, A-71, Cleveland, OH, 44195, USA.
William S TierneyCleveland Clinic Voice Center, Head and Neck Institute, 9500 Euclid Ave, A-71, Cleveland, OH, 44195, USA.
Ian GriffithsCleveland Clinic Voice Center, Head and Neck Institute, 9500 Euclid Ave, A-71, Cleveland, OH, 44195, USA.
Rebecca C NelsonCleveland Clinic Voice Center, Head and Neck Institute, 9500 Euclid Ave, A-71, Cleveland, OH, 44195, USA.
Paul C BrysonCleveland Clinic Voice Center, Head and Neck Institute, 9500 Euclid Ave, A-71, Cleveland, OH, 44195, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough injection pharyngoplasty (IP) has been well described as a treatment for velopharyngeal insufficiency (VPI) in the pediatric population, there are far fewer studies on its safety and effectiveness in adults with acquired VPI. Our study aims to characterize the safety and efficacy of IP as a treatment for acquired VPI in adults while identifying underlying VPI etiologies and injection characteristics that are associated with positive outcomes.

methodsWe conducted a retrospective analysis of 30 adult patients with acquired VPI who were treated with IP. We collected data on patient demographics, etiology of acquired VPI, and IP procedural characteristics for analysis. Descriptive statistics are provided for patient demographic and IP procedural characteristics.

resultsIn our cohort, 16 patients had a history of radiation and/or chemotherapy while 14 patients had acquired VPI due to other etiologies. A majority of patients (n = 16) in our study had their VPI resolved with a single injection. Of all 61 injections recorded in our cohort, the most frequent injection agent was calcium hydroxyapatite (n = 35) followed by autologous fat (n = 15). We found that 27 of the patients in our cohort reported improvement in their acquired VPI after IP with only 9 reporting temporary minor complications that were resolved without intervention.

conclusionOur study further establishes IP as a safe and effective procedure for adult patients with acquired VPI.

Indexed as

DurapatitePharynxVelopharyngeal InsufficiencyAdultAgedFemaleHumansInjectionsMaleMiddle AgedRetrospective StudiesTreatment OutcomeYoung AdultDurapatiteAugmentationAutologous fatCalcium hydroxyapatiteInjection pharyngoplastyVelopharyngeal insufficiency

Identifiers

PMID41222636
PMCPMC12904939

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.