Evidence map›Paper›PMID 41222595›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026

Degenerative scoliosis may trigger higher incidence of adjacent vertebral fractures following percutaneous vertebroplasty: a clinical evidence-based biomechanical research.

Pengfei Yu, Zhenyu Tang, Wenjie Chang, Lijunpeng Jia, Zhijia Ma, Hongwei Li, Jintao Liu, Jingchi Li

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Pengfei Yu *Department of Orthopedics, Suzhou TCM Hospital, Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Zhenyu Tang *Department of Orthopedics, Suzhou TCM Hospital, Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Wenjie ChangDepartment of Orthopedics, Suzhou TCM Hospital, Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Lijunpeng JiaDepartment of Orthopedics, Luzhou Key Laboratory of Orthopedic Disorders, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Sichuan Province, Luzhou, People's Republic of China.
Zhijia MaDepartment of Orthopedics, Suzhou TCM Hospital, Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Hongwei LiDepartment of Orthopedics, Suzhou TCM Hospital, Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China.
Jintao LiuDepartment of Orthopedics, Suzhou TCM Hospital, Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China. okdoctor@163.com.
Jingchi LiDepartment of Orthopedics, Luzhou Key Laboratory of Orthopedic Disorders, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Sichuan Province, Luzhou, People's Republic of China. lijingchi9405@163.com.ORCID http://orcid.org/0009-0001-3411-4810

Funding

Jiangsu Province Leading Talents Cultivation Project for Traditional Chinese Medicine NO.SLJ0310Jiangsu Provincial Administration of Traditional Chinese Medicine Project ZD202326
6 · The paper itself

Abstract

Degenerative scoliosis can increase stress on nearby vertebrae after vertebroplasty, raising the risk of new fractures. Our clinical and biomechanical findings show that patients with scoliosis are more vulnerable, highlighting the need for closer monitoring and preventive strategies in this high-risk group.

backgroundAdjacent vertebral fracture (AVF) is a common complication following percutaneous vertebroplasty (PVP). Degenerative scoliosis (DS), a manifestation of spinal degeneration, frequently occurs in elderly patients with osteoporotic vertebral compression fractures (OVCF). However, whether local DS increases AVF incidence remains unclear.

methodsOn immediate postoperative anterior-posterior radiographs, the scoliosis angle was measured between adjacent cranial and caudal vertebrae. DS was defined as a scoliosis angle > 10°. We compared this angle and DS incidence between patients with and without AVF, performed regression analyses to identify AVF risk factors, and calculated stress values in vertebrae adjacent to PVP-treated levels using biomechanical models with varying scoliosis angles.

resultsPatients with AVF exhibited significantly larger scoliosis angles and higher DS incidence than those without AVF. Both parameters were independent risk factors for AVF. Biomechanical models with pronounced scoliosis showed markedly higher stress in adjacent vertebrae under most loading conditions compared to non-scoliotic or mildly scoliotic models.

conclusionSupported by consistent clinical and biomechanical evidence, DS is associated with a higher incidence of AVF, likely due to biomechanical factors, and patients with DS should be considered high-risk after PVP.

Indexed as

Fractures, CompressionOsteoporotic FracturesScoliosisSpinal FracturesVertebroplastyAgedAged, 80 and overBiomechanical PhenomenaEvidence-Based MedicineFemaleHumansIncidenceMaleMiddle AgedPostoperative ComplicationsRadiographyAdjacent vertebral fractureDegenerative scoliosisOsteoporotic vertebral compressive fracturePercutaneous vertebroplastyStress concentration

Identifiers

PMID41222595

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.