Evidence map›Paper›PMID 41222455›Full record

ArticleeLife2025

Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in

Jayati Gera, Marishia Agard, Hannah Nave, Austin B Baldridge, Farwa Sajadi, Leena Thorat, Theresa H McKim, Shu Kondo, Dick R Nässel, Mitchell H Omar and 2 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Toxins in disguise: Neuropeptide mimicry across animal venoms.General and comparative endocrinology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Synaptic connectome of a neurosecretory network in thebioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jayati GeraNeurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, Julius-Maximilians-University of Würzburg, Am Hubland, Würzburg, Germany.ORCID https://orcid.org/0000-0002-4744-1546
Marishia Agard *Department of Biology, York University, Toronto, Canada.ORCID https://orcid.org/0009-0009-1463-6409
Hannah Nave *Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, Julius-Maximilians-University of Würzburg, Am Hubland, Würzburg, Germany.
Austin B Baldridge *Department of Biochemistry and Molecular Biology, University of Nevada, Reno, United States.
Farwa SajadiDepartment of Biology, York University, Toronto, Canada.
Leena ThoratDepartment of Biology, York University, Toronto, Canada.
Theresa H McKimDepartment of Biology, University of Nevada, Reno, United States.ORCID https://orcid.org/0000-0002-8501-6487
Shu KondoDepartment of Biological Science and Technology, Tokyo University of Science, Tokyo, Japan.ORCID https://orcid.org/0000-0002-4625-8379
Dick R NässelDepartment of Zoology, Stockholm University, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-1147-7766
Mitchell H OmarDepartment of Biochemistry and Molecular Biology, University of Nevada, Reno, United States.ORCID https://orcid.org/0000-0002-1713-4473
Jean-Paul PaluzziDepartment of Biology, York University, Toronto, Canada.ORCID https://orcid.org/0000-0002-7761-0590
Meet ZandawalaNeurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, Julius-Maximilians-University of Würzburg, Am Hubland, Würzburg, Germany.ORCID https://orcid.org/0000-0001-6498-2208

Funding

Outreach/Diversity/Pipeline ProjectP20GM103440 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Eduardo A Robleto · 2012 to 2026
$58.0M
Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Yumei Feng Earley · 2019 to 2026
$20.3M
Dissemination of FlyWire, A Whole-Brain Connectomics ResourceU24NS126935 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2022 to 2026
$5.6M
Crowdsourcing the Fly ConnectomeRF1MH117815 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA, SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$3.3M
Deutsche Forschungsgemeinschaft ZA1296/1-1Japan Society for the Promotion of Science 20H03246Natural Sciences and Engineering Research Council of Canada CGS-DNatural Sciences and Engineering Research Council of Canada Discovery GrantNatural Sciences and Engineering Research Council of Canada PGS-DNIGMS NIH HHS GM103440NIGMS NIH HHS P20 GM103440NIGMS NIH HHS P20 GM130459NIGMS NIH HHS P20GM130459NIMH NIH HHS RF1 MH117815NINDS NIH HHS U24 NS126935Ontario Ministry of Research and Innovation Early Researcher AwardVetenskapsrådet 2015-04626
6 · The paper itself

Abstract

Insects have evolved a variety of neurohormones that enable them to maintain nutrient and osmotic homeostasis. Here, we characterized the ion transport peptide (ITP) signaling system in

Indexed as

Drosophila melanogasterDrosophila ProteinsGuanylate CyclaseHomeostasisSignal TransductionAnimalsDrosophila ProteinsGuanylate Cyclaseatrial natriuretic peptidecomputational biologyconnectomicsD. melanogasterendocrine signalingmetabolismneuropeptideneuroscienceosmoregulationsystems biology

Identifiers

PMID41222455
PMCPMC12611267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.