ArticleNanomaterials (Basel, Switzerland)2025
Application of Amino Acid-Based Carbon Dots for the Treatment of Oral Bacteria and Oral Cancer Cells In Vitro Using a Dental Light-Curing Unit via ROS-Mediated Therapy.
Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Antipathogenic carbon dots synthesized from fluorescent amino acids and their photodynamic activity.Discover nano · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
In systemic diseases, controlling oral bacteria and cancer is an important issue. As biomaterials, recently, carbon dots (DSs) are the focus of a variety of studies owing to their extensive applicability in life sciences. In this study, the effectiveness of carbon dots (CDs) for the elimination of both oral bacteria and oral cancer in vitro was assessed using a dental light-curing unit (LCU) as a light source. CDs were synthesized using an amino acid. The absorbance of CDs and the emission spectrum of the LCU were measured. The production of reactive oxygen species (ROS) was evaluated spectroscopically. Changes in glutathione (GSH) content were evaluated. Using oral bacteria and cancer cells, in vitro antibacterial and antitumor capabilities of CDs were evaluated under light irradiation. Confocal microscopy was used to observe live/dead cells and intracellular lipid peroxidation (LPO). The emission spectrum of the LCU fully matched the absorbance of CDs. After CD treatment, the initial peak absorbances of the p-nitrosodimethylaniline-imidazole (for singlet oxygen assay) and nitroblue tetrazolium (for superoxide oxide assay) solutions changed under light irradiation. The initial peak absorbance of the GSH assay solution decreased during and after light irradiation. Both CD-treated oral bacteria and oral cancer cells were near totally eliminated at 50 and 200 μg/mL concentrations, respectively, after light irradiation. In the live/dead cell and C11-BODIPY
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