ArticleSmall (Weinheim an der Bergstrasse, Germany)2025
Design of a Trigger-Responsive Photothermal Vesicle-Based Cargo Delivery Platform.
Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Oxygen-Independent Supramolecular Nanoplatform for Photothermal-Thermodynamic Therapy Against Periodontal Anaerobic Infections.Advanced healthcare materials · 2026Article
- Near Infrared Laser-Induced Content Release from Magnetic Bead-Encapsulated Giant Unilamellar Vesicles.microPublication biology · 2026Article
- Design of a Trigger-Responsive Photothermal Vesicle-Based Cargo Delivery Platform.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Cargo delivery systems enable the targeted transport of therapeutic agents to specific sites, enhancing treatment efficacy while minimizing systemic side effects. However, many existing systems struggle with achieving precise control over the release timing. Here, a photothermal trigger-responsive delivery platform based on Giant Unilamellar Vesicles (GUVs) functionalized with gold nanorods (GNRs) is described to overcome these challenges. Toward this end, cargo-loaded GUVs are produced using the emulsion transfer method and effective GNR attachment to the vesicle membrane is achieved by functionalizing the GNRs with cholesterol. The near-infrared light (NIR)-mediated cargo release mechanism is described. Importantly, high release efficiency is achieved by optimizing the cholesterol concentration on the GNRs, which is essential for controlling the GNR attachment mechanism to the GUV membrane. Finally, GNR-functionalized ampicillin-loaded GUVs are tested in the presence of E. coli bacteria to demonstrate the platform's functionality. Following NIR-triggered antibiotic release, bacterial growth is inhibited. This showcases the practical potential of the developed trigger-responsive system. Notably, GNR-mediated photothermal heating alone also reduces bacterial viability upon extended illumination, indicating a dual antibacterial mechanism. This versatile and biocompatible system offers a controlled delivery method with broad applicability for therapeutics, diagnostics, and other biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.