ArticleJournal of bacteriology2025
Overexpression of 2-mercaptoethanesulfonate biosynthesis genes
Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Coenzyme M (2-mercaptoethane sulfonate, CoM) is an essential low-molecular-weight thiol in methanogenic archaea (methanogens) that serves as a methyl carrier and as a component of CoM-S-S-CoB heterodisulfide comprising CoM and coenzyme B (7-mercaptoheptanoylthreoninephosphate), which serves as the terminal electron acceptor in methanogenesis. Increasing the amount of CoM in IMPORTANCE: Methanogens are key organisms in the global carbon cycle with potential to be harnessed to produce renewable energy and transportation fuel. Methanogens are strict anaerobes found in subsurface sediment, anaerobic digesters, and digestive tracts of animals such as the rumen. Our results suggest methanogens can adapt to prolonged exposure to oxidative stress under the appropriate environmental conditions, and it may be possible to engineer thiol redox homeostasis and oxidative stress resistance in methanogens. Engineering redox homeostasis and oxidative stress resistance in methanogens and other strict anaerobes has the potential to reduce technical barriers to culturing, thus accelerating research progress on a wide variety of non-model microbes, and ultimately broadening potential biotechnology applications related to sustainable food, fuel, and biomedical uses.
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