Evidence map›Paper›PMID 41222260›Full record

ArticleAntimicrobial agents and chemotherapy2025

Pharmacokinetic/pharmacodynamic optimization of temocillin treatment against CTX-M-15-producing

José Luis Rodríguez-Ochoa, Carlos Saúco-Carballo, Patricia Pérez-Palacios, Vicente Merino-Bohórquez, Ana Velázquez-Escudero, Lorena López-Cerero, Jesús Rodríguez-Baño, José Manuel Rodríguez-Martínez, Álvaro Pascual, Fernando Docobo-Perez

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

José Luis Rodríguez-OchoaUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain.ORCID 0009-0005-3603-6800
Carlos Saúco-CarballoUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain.ORCID 0000-0002-4428-3917
Patricia Pérez-PalaciosUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain.ORCID 0000-0002-3775-5330
Vicente Merino-BohórquezInstituto de Biomedicina de Sevilla IIIS, Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Seville, Spain.ORCID 0000-0002-0315-3411
Ana Velázquez-EscuderoUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain.
Lorena López-CereroUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain.ORCID 0000-0001-8950-4384
Jesús Rodríguez-BañoUnidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain.ORCID 0000-0001-6732-9001
José Manuel Rodríguez-MartínezInstituto de Biomedicina de Sevilla IIIS, Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Seville, Spain.ORCID 0000-0002-2228-2294
Álvaro Pascual *Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain.ORCID 0000-0002-8672-5891
Fernando Docobo-Perez *Instituto de Biomedicina de Sevilla IIIS, Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Seville, Spain.ORCID 0000-0003-4038-6764

Funding

Instituto de Salud Carlos III CM23/00033Instituto de Salud Carlos III FI23/00026Instituto de Salud Carlos III PI22/00914Junta de Andalucía P20-00985
6 · The paper itself

Abstract

Temocillin, a β-lactam antibiotic, has been proposed as an alternative to carbapenems for the treatment of ESBL-producing Enterobacteriaceae. The present EUCAST breakpoints for temocillin are established based on exposure levels derived from a dosing regimen of 2 g every 8 h via intermittent infusion (II). However, the evidence supporting the efficacy of continuous infusion (CI) against ESBL-producing

Indexed as

Anti-Bacterial Agentsbeta-LactamasesKlebsiella InfectionsKlebsiella pneumoniaePenicillinsHumansMicrobial Sensitivity TestsWhole Genome SequencingAnti-Bacterial Agentsbeta-lactamase CTX-M-15beta-LactamasesPenicillinstemocillinhollow-fibertemocillinWGS

Identifiers

PMID41222260
PMCPMC12691685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.