ArticleJournal of cosmetic dermatology2025
Anti-Pruritic and Analgesic Effects of a Topical Formulation Containing Troxerutin: A Pilot Study.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A Metabolism-Guided Framework for Selecting Structural Modification or Nano-Delivery Strategies for Oral Rutin.International journal of molecular sciences · 2026Review
- Anti-Pruritic and Analgesic Effects of a Topical Formulation Containing Troxerutin: A Pilot Study.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundSensitive skin is often characterized by increased sensitivity to environmental and cosmetic stimuli, leading to pruritus and pain. Current treatments remain inadequate, leaving many affected individuals in discomfort. Troxerutin, a TRPV1-inhibiting material, has shown potential in alleviating these symptoms by improving skin barrier function.
objectiveThis study evaluates the efficacy of a topical formulation containing troxerutin in reducing skin sensitivity, improving hydration, and enhancing the quality of life in individuals with sensitive skin.
methodAdult participants over 20 years old with clinically diagnosed sensitive skin applied a troxerutin-containing moisturizer twice daily for 8 weeks. The effects were assessed using transepidermal water loss (TEWL), stratum corneum hydration (SCH), Sensitive Scale-10 (SS-10), and Dermatology Life Quality Index (DLQI). Measurements were taken at baseline, 2, 4, and 8 weeks.
resultsTwenty adult participants who were clinically diagnosed with sensitive skin were registered. Statistically significant reductions in TEWL were observed at 2 weeks (p = 0.047) and 4 weeks (p = 0.021), indicating an improvement in skin barrier function. SCH significantly increased after 2 and 4 weeks (p = 0.007, p = 0.002). SS-10 scores improved markedly, from 64.17 ± 12.96 at baseline to 39.84 ± 17.00 at 8 weeks (p < 0.001), suggesting decreased skin sensitivity. The DLQI score improved from 18.60 ± 5.00 to 8.50 ± 5.10 (p = 0.000), highlighting enhanced quality of life. Additionally, regional facial erythema-most notably in the cheeks and nose-was significantly reduced after 4 weeks of treatment, indicating a beneficial effect on localized vascular reactivity.
conclusionTroxerutin significantly reduces pruritus and pain in individuals with sensitive skin and enhances skin barrier function and hydration, ultimately improving overall skin comfort and patient satisfaction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.