Evidence map›Paper›PMID 41222116›Full record

ArticleAdvanced biology2025

Osteogenic Effects of Ion Released from Biodegradable Metallic Magnesium and Calcium Coating.

Risa Miyake, Masaya Shimabukuro, Masahiko Terauchi, Eriko Marukawa, Masakazu Kawashita

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Risa MiyakeDepartment of Regenerative and Reconstructive Dental Medicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.ORCID 0009-0008-2279-8195
Masaya ShimabukuroDepartment of Inorganic Biomaterials, Laboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, 2-3-10, Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.ORCID 0000-0002-0364-8721
Masahiko TerauchiDepartment of Regenerative and Reconstructive Dental Medicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
Eriko MarukawaDepartment of Regenerative and Reconstructive Dental Medicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
Masakazu KawashitaDepartment of Inorganic Biomaterials, Laboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, 2-3-10, Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.

Funding

Cooperative Research Project of Research Center for Biomedical EngineeringGrant-in-Aid for Scientific Research JP24K12981Japan Society for the Promotion of Science JP24K12981JST SPRING JPMJSP2180METI R&D Support Program for Growth-oriented Technology SMEs JPJ005698Ministry of Education, Culture, Sports, Science and TechnologyProject on Design & Engineering by Joint Inverse Innovation for Materials ArchitectureYoung Innovative Medical Scientist Unit
6 · The paper itself

Abstract

This study investigates the effects of ion release and pH elevation from a biodegradable metallic magnesium (Mg) -30 calcium (Ca) coating on osteogenesis using osteoblast-like cells. The coating, formed on titanium (Ti) via magnetron sputtering, has previously been shown to enhance osteogenesis by promoting calcite formation on the Ti surface upon degradation in vitro study. However, the individual and combined roles of released Mg

Indexed as

CalciumCoated Materials, BiocompatibleMagnesiumOsteoblastsOsteogenesisAlkaline PhosphataseAlloysAnimalsCell LineCell ProliferationHydrogen-Ion ConcentrationIonsMiceTitaniumAlkaline PhosphataseAlloysCalciumCoated Materials, BiocompatibleIonsMagnesiumTitaniumbiodegradable metalsdental implantsion releaseosteoblastsosteogenesispH elevation

Identifiers

PMID41222116
PMCPMC12712752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.