ArticleJournal of feline medicine and surgery2026
Comparison of thyrotropin concentrations measured by bulk acoustic wave technology and chemiluminescence in hyperthyroid cats and cats with non-thyroidal illness.
Article in Journal of feline medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectivesA thyrotropin (also known as thyroid-stimulating hormone [TSH]) assay using bulk acoustic wave (TSH-BAW) technology is a sensitive and specific test for diagnosing hyperthyroidism; however, the effect of various types of non-thyroidal illness (NTI) have not been evaluated with this assay. The objectives of this study were to compare serum TSH concentrations using the TSH-BAW and a currently available TSH chemiluminescent immunoassay (TSH-CLIA) in hyperthyroid cats, cats with NTI and healthy cats, as well as to compare sensitivity and specificity for diagnosing hyperthyroidism.MethodsA prospective cross-sectional study was conducted comparing the TSH concentration of 37 hyperthyroid, 32 healthy and 32 NTI cats using the TSH-CLIA and TSH-BAW assays. The effect of disease severity was evaluated with hyperthyroidism and NTI.ResultsThe TSH-BAW had a lower sensitivity (78%, 95% confidence interval [CI] 62-90) and negative predictive value (89%, 95% CI 79-95) but higher specificity (97%, 95% CI 89-100) and positive predictive value (94%, 95% CI 79-99) than the TSH-CLIA. The median serum TSH concentration was significantly different between hyperthyroid cats and both healthy and NTI cats with both assays (
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