ArticlePediatric pulmonology2025
Using Positive End-Expiratory Pressure to Predict and Quantify Tracheobronchomalacia in Grade 3 Bronchopulmonary Dysplasia.
Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Using Positive End-Expiratory Pressure to Predict and Quantify Tracheobronchomalacia in Grade 3 Bronchopulmonary Dysplasia.Pediatric pulmonology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectivesTracheobronchomalacia (TBM) is common in Grade 3 Bronchopulmonary Dysplasia (BPD), but there is wide variation in frequency and method of evaluation. Objective quantitative methods are needed for translational studies and future drug trials. This study aimed to determine whether positive end-expiratory pressure (PEEP) and oxygen saturation index (OSI) can predict TBM in Grade 3 BPD.
methodsWe retrospectively reviewed flexible bronchoscopy videos from a cohort of infants with Grade 3 BPD to determine the presence of TBM. PEEP and mean OSI in the week before the first bronchoscopy were assessed as predictors of TBM using multiple logistic regression. Subject Demographics: The study included 56 infants with Grade 3 BPD with a median gestational age (GA) of 25.3 weeks (IQR 2.8) and median post-menstrual age (PMA) at first bronchoscopy of 40.7 weeks (IQR 6.1).
resultsThirty-seven subjects (66%) were found to have TBM, although 13 subjects lacked evidence of TBM on the first evaluation (false negative rate 35%). PEEP and OSI had 86% sensitivity for predicting TBM, but only 30% specificity (p = 0.02). In a post-hoc analysis of the 13 initial bronchoscopies that "missed" TBM, 10 had a higher level of sedation in the first evaluation compared to the later assessment that revealed TBM.
conclusionsWe found that PEEP and OSI are sensitive but not specific for predicting TBM in Grade 3 BPD. In addition, there are frequent false negative evaluations when bronchoscopy is performed under higher levels of sedation. We propose a more precise bronchoscopy method for quantifying TBM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.