Evidence map›Paper›PMID 41222000›Full record

ArticleeLife2025

SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice.

Daisuke Mashiko, Shingo Tonai, Haruhiko Miyata, Martin M Matzuk, Masahito Ikawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Sperm and offspring production in a nonobstructive azoospermia mouse model via testicular mRNA delivery using lipid nanoparticles.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Daisuke MashikoDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan.ORCID https://orcid.org/0000-0003-3927-3076
Shingo TonaiDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan.
Haruhiko MiyataDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan.ORCID https://orcid.org/0000-0003-4758-5803
Martin M MatzukDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0002-1445-8632
Masahito IkawaDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan.ORCID https://orcid.org/0000-0001-9859-6217

Funding

Functional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD088412Gates Foundation INV-001902Japan Agency for Medical Research and Development JP23fa627002Japan Agency for Medical Research and Development JP23fa627006Japan Agency for Medical Research and Development JP23jf0126001Japan Science and Technology Agency 10.52926/jpmjcr21n1Japan Science and Technology Agency 10.52926/jpmjfr211fJapan Society for the Promotion of Science JP21H05033Japan Society for the Promotion of Science JP21K19569Japan Society for the Promotion of Science JP22H03214Japan Society for the Promotion of Science JP22H04922Japan Society for the Promotion of Science JP23K20043NICHD NIH HHS R01 HD088412Osaka University OU Master Plan Implementation Project
6 · The paper itself

Abstract

Despite the recognized importance of glycans in biological phenomena, their complex roles in spermatogenesis and sperm function remain unclear. SLC35G3, a 10-transmembrane protein specifically found in early round spermatids, belongs to the sugar-nucleotide transporter family, indicating its involvement in glycan formation. In this study, we found that

Indexed as

FertilityGlycoproteinsInfertility, MaleNucleotide Transport ProteinsSpermatozoaAnimalsFemaleMaleMiceMice, KnockoutGlycoproteinsNucleotide Transport Proteinsdevelopmental biologymousesterilityutero tubal junction penetrationzona pellucida binding

Identifiers

PMID41222000
PMCPMC12611266

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.