Evidence map›Paper›PMID 41221847›Full record

ArticleJournal of cellular biochemistry2025

Bmpr2 Loss in the Vascular Endothelium Enhances Neoangiogenesis and Growth of Lung Metastatic Lesions in a Mouse Model of Breast Cancer.

Jordan A Harry, Sofia I Skebo, Devon V Cole, Vincent Dinh, M Martin VandenBroek, Abby K Lee, Natasha Camacho, Hollie N Piepjohn, Victoria Hoskin, Kimberly J Laverty and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jordan A HarryDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Sofia I SkeboDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Devon V ColeDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Vincent DinhDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
M Martin VandenBroekDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Abby K LeeDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Natasha CamachoDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Hollie N PiepjohnDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Victoria HoskinDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Kimberly J LavertyDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Yan GaoDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Douglas QuiltyDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Peter A GreerDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Mark L OrmistonDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.

Funding

This study was funded in part by Canadian Institutes of Health Research project grants to MLO (PJT-178078) and PAG (PJT-166062).
6 · The paper itself

Abstract

Bone morphogenetic protein-9 (BMP9) has been implicated as a regulator of metastasis and tumor angiogenesis, with contrasting studies demonstrating both pro- and antiangiogenic roles for BMP9 across different cancer cell lines and animal models. However, these works have yet to define the contribution of the type-II BMP receptor (BMPR-II) to these processes, or assess whether the effects of BMP9 are mediated via actions on the endothelium, the tumor, or its microenvironment. Here, we demonstrate that the heterozygous (Bmpr2

Indexed as

Bone Morphogenetic Protein Receptors, Type IIBreast NeoplasmsEndothelium, VascularLung NeoplasmsNeovascularization, PathologicAnimalsCell Line, TumorDisease Models, AnimalFemaleGrowth Differentiation Factor 2HumansMiceMice, KnockoutBmpr2 protein, mouseBone Morphogenetic Protein Receptors, Type IIGrowth Differentiation Factor 2angiogenesisbone morphogenetic protein 9 (BMP9)bone morphogenetic protein type II receptor (BMPR‐II)breast cancermetastasisneovascularizationvascular endothelial growth factor

Identifiers

PMID41221847
PMCPMC12606701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.