Evidence map›Paper›PMID 41221797›Full record

ArticleObesity (Silver Spring, Md.)2026

The Uncharted Territory of the New Obesity Drugs in Users Without Obesity: A Sociomedical Perspective.

Fernanda Baeza Scagliusi, Bruno Gualano, Pernille Andreassen, Cindi SturtzSreetharan, Sissel Due Jensen, Alexandra Brewis

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fernanda Baeza ScagliusiDepartment of Nutrition, Research Group in Eating, Corporalities and Culture (GPAC), University of São Paulo School of Public Health, São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7590-4563
Bruno GualanoDepartment of Clinical Medicine, Center for Lifestyle Medicine (CMEV), University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7100-8681
Pernille AndreassenThe Danish National Center for Obesity, Aarhus University Hospital, Aarhus, Jutland, Denmark.
Cindi SturtzSreetharanArizona State University, School of Human Evolution and Social Change, Center for Global Health, Tempe, Arizona, USA.
Sissel Due JensenDepartment of Public Health, Aarhus University, Aarhus, Jutland, Denmark.
Alexandra BrewisArizona State University, School of Human Evolution and Social Change, Center for Global Health, Tempe, Arizona, USA.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304385/2021-2Conselho Nacional de Desenvolvimento Científico e Tecnológico 304698/2025-3
6 · The paper itself

Abstract

The off-label use of glucagon-like peptide-1 receptor agonists (GLP-1ra) among people without obesity and/or diabetes is rapidly expanding, despite a lack of clinical justification or safety data in this population. This Perspective explores the sociomedical dimensions of this trend, highlighting key research gaps and emerging hypotheses around the off-label use of GLP-1ra to an individual goal of slimness rather than health. We propose that off-label GLP-1ra use by people with normative or mildly elevated weight reveals deeper tensions between scientific progress, stigma, and cultural ideals of the body. Understanding this phenomenon requires moving beyond biomedical efficacy to interrogate the psychological, behavioral, and sociopolitical implications of pharmacological thinness. Cross-cultural and intersectional approaches from the social sciences are key to understanding this emergent phenomenon.

Indexed as

Anti-Obesity AgentsGlucagon-Like Peptide-1 Receptor AgonistsObesityOff-Label UseHumansSocial StigmaAnti-Obesity AgentsGlucagon-Like Peptide-1 Receptor Agonistsanti‐obesity drugsobesityoff‐label useslimnesssociomedical aspects

Identifiers

PMID41221797
PMCPMC13535755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.