Evidence map›Paper›PMID 41221725›Full record

SynthesisActa psychiatrica Scandinavica2026

Resilience in Bipolar Disorder Compared to Clinical and Non-Clinical Populations: A Systematic Review and Meta-Analysis.

Derek Clougher, Michele De Prisco, Brisa Solé, Laura Montejo, Maria Serra-Navarro, Maria Florencia Forte, Patricia Camprodon-Boadas, Elena de la Serna, Vincenzo Oliva, Sara Martin-Parra and 10 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Acta psychiatrica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Derek ClougherDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.ORCID 0000-0001-7631-3845
Michele De PriscoDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.
Brisa SoléDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.
Laura MontejoDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.
Maria Serra-NavarroDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.
Maria Florencia ForteDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.
Patricia Camprodon-BoadasDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.
Elena de la SernaDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.
Vincenzo OlivaDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.
Sara Martin-ParraBipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona, Barcelona, Spain.
Jose Sánchez-MorenoDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.
Benedikt L AmannDepartment of Psychiatry, Hospital del Mar, Hospital del Mar Medical Research Institute, University Pompeu Fabra, Barcelona, Spain.ORCID 0000-0002-4407-1519
Marina GarrigaDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.ORCID 0000-0001-7312-4969
Norma VerdoliniLocal Health Unit Umbria 1, Department of Mental Health, Mental Health Center of Perugia, Perugia, Italy.ORCID 0000-0001-9488-2881
Marta RibasesGroup of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain.
Kamilla MiskowiakNeurocognition and Emotion Across Disorders of the Brain Centre (NEAD), Copenhagen Mental Health Centre, Frederiksberg Hospital, Frederiksberg, Denmark.
Anabel Martínez-AranDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.
Eduard VietaDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.ORCID 0000-0002-0548-0053
Silvia AmorettiDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.
Carla TorrentDepartament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB), Barcelona, Spain.

Funding

Department of Research and Universities of the Generalitat de CatalunyaEuropean Social Fund "Investing in your future" La Marató-TV3 Foundation 202234-30European Social Fund "Investing in your future" La Marató-TV3 Foundation 202234-32European Union (FEDER) "Una manera de hacer Europa" and Project 2021-SGR-1358Instituto de Salud Carlos III PI20/00344Instituto de Salud Carlos III PI21/00787Instituto de Salud Carlos III PI24/00407Instituto de Salud Carlos III PI24/00432Instituto de Salud Carlos III PI24/00671Instituto de Salud Carlos III (ISCIII)M-AES Mobility Fellowship MV22/00002Sara Borrell Doctoral Programme CD20/00177
6 · The paper itself

Abstract

introductionResilience is present in both clinical and non-clinical populations; yet, there is a paucity of literature examining its role in bipolar disorder (BD). The goal of the present systematic review and meta-analysis was to substantiate the extant literature investigating resilience in BD in comparison to clinical and non-clinical populations.

methodPubMed/MEDLINE, PsycINFO, and Scopus were systematically searched from inception to August 8th, 2024.

resultsTwenty-eight studies using a validated resilience scale with a total of 3094 people with BD, 4100 healthy controls, and 1768 with other mental diagnoses were included in the systematic review, and 21 were analyzed in a random effects meta-analysis. A statistically significant result with a medium effect (SMD = -0.787, p < 0.001) indicated that people with BD reported lower levels of resilience than healthy controls. Similarly, patients with BD showed higher levels of resilience than patients with schizophrenia (SCZ) (SMD = 0.336, p = 0.013). No significant differences were found between BD and major depressive disorder (MDD).

conclusionFindings should be interpreted with caution due to the high heterogeneity observed and methodological challenges in the definition and measurement of resilience. Future research should aim to better characterize resilience in BD by improving its assessment as a standardized element of clinical evaluation. This will provide a basis for strategies to reduce the burden of this chronic condition.

Indexed as

Bipolar DisorderMajor Depressive DisorderResilience, PsychologicalSchizophreniaHumansbipolar disordermeta‐analysisresiliencesevere mental illnesssystematic review

Identifiers

PMID41221725
PMCPMC12668893

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.