Evidence map›Paper›PMID 41221660›Full record

ArticlePlant biotechnology journal2026

Effector-Mediated Spatial Reprogramming of Glycolate Oxidase Subverts Peroxisomal and Membrane-Associated ROS Defences.

Junjian Situ, Zijing Zhang, Yi Shao, Jiaying Feng, Feiteng Zhong, Muran Xiong, Wen Li, Peng Li, Xiaofan Zhou, Guibing Hu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Junjian SituNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.
Zijing ZhangNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.
Yi ShaoNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.
Jiaying FengNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.
Feiteng ZhongNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.
Muran XiongNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.
Wen LiNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.
Peng LiNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.
Xiaofan ZhouNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.
Guibing HuState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (South China), Ministry of Agriculture and Rural Affairs/Guangdong Litchi Engineering Research Center, College of Horticulture, South China Agricultural University, Guangzhou, China.
Jietang ZhaoState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources/Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (South China), Ministry of Agriculture and Rural Affairs/Guangdong Litchi Engineering Research Center, College of Horticulture, South China Agricultural University, Guangzhou, China.ORCID https://orcid.org/0000-0003-4330-5480
Minhui LiNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.
Pinggen XiNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.
Xinxiang PengState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources/College of Life Sciences, South China Agricultural University, Guangzhou, China.ORCID https://orcid.org/0000-0001-6581-0555
Zide JiangNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.
Guanghui KongNational Key Laboratory of Green Pesticide/Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China.ORCID https://orcid.org/0000-0002-7295-3471

Funding

modern agriculture technology system of Guangdong Province 2024CXTD19National Natural Science Foundation of China 32300166National Natural Science Foundation of China U21A20220Natural Science Foundation of Guangdong Province 2022A1515010458Natural Science Foundation of Guangdong Province 2023A1515012617Natural Science Foundation of Guangdong Province 2023A1515030267Science and Technology Planning Project of Guangzhou 2023B01J2002
6 · The paper itself

Abstract

Oomycete pathogens secrete hundreds of RXLR effectors into plant cells to modulate host immunity by targeting diverse plant proteins. Here, we report that the Peronophythora litchii RXLR effector PlAvh133 acts as a virulence factor and targets the litchi glycolate oxidase (GLO) LcGLO1, a key enzyme in photorespiration, thereby suppressing plant immunity. PlAvh133 localises to the plasma membrane (PM) in planta, and its first α-helix is vital for both its LcGLO1-binding activity and proper PM localisation. LcGLO1 is mainly confined to the peroxisomes, and its overexpression significantly enhanced resistance to downy blight in litchi. Conversely, silencing the Nicotiana benthamiana homologue of LcGLO1 increases plant susceptibility to the oomycete pathogen. Critically, PlAvh133 causes the relocation of LcGLO1 from peroxisomes to the PM and inhibits its enzymatic activity, leading to increased plant susceptibility. PM-localised LcGLO1 cooperates with catalase (CAT) LcCATB to suppress reactive oxygen species (ROS) burst. Meanwhile, PM-localised LcGLO1 destabilises respiratory burst oxidase homologue (RBOH) LcRBOHD by interacting with calcium-dependent protein kinase (CPK) LcCPK5, further reducing ROS production. Taken together, our findings unveil an unprecedented virulence mechanism by which a pathogen effector relocalises and inhibits host GLO1 activity, thereby simultaneously diminishing ROS production from both the peroxisomes and PM-localised RBOHD.

Indexed as

Alcohol OxidoreductasesPeroxisomesReactive Oxygen SpeciesCell MembraneNicotianaPlant DiseasesPlant ImmunityPlant ProteinsAlcohol Oxidoreductasesglycollate oxidasePlant ProteinsReactive Oxygen SpecieslitchiPeronophythora litchiiphotorespirationROS homeostasisRXLR effector

Identifiers

PMID41221660
PMCPMC13140691

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.