Evidence map›Paper›PMID 41221589›Full record

ArticleCirculation2026

N-Palmitoyl Glutamine Is a Candidate Mediator of Cardiorespiratory Fitness.

Jeremy M Robbins, Mark Benson, Anthony R P Verkerke, Gaurav Tiwari, Shuliang Deng, Prashant Rao, Usman A Tahir, Julian Avila-Pacheco, Xu Shi, Yuntian Guan and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Jeremy M RobbinsDivision of Cardiovascular Medicine (J.M.R., M.B., P.R., U.A.T., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0002-9672-4841
Mark BensonDivision of Cardiovascular Medicine (J.M.R., M.B., P.R., U.A.T., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.
Anthony R P VerkerkeDivision of Endocrinology, Diabetes and Metabolism (A.R.P.V., S.K.), Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0002-6198-4723
Gaurav TiwariCardiovascular Research Center (J.M.R., M.B., G.T., S.D., P.R., U.A.T., X.S., Y.G., F.-G.T., J.L.B., J.G.W., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.t.ORCID 0009-0000-2540-6005
Shuliang DengCardiovascular Research Center (J.M.R., M.B., G.T., S.D., P.R., U.A.T., X.S., Y.G., F.-G.T., J.L.B., J.G.W., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.t.ORCID 0000-0002-1543-2733
Prashant RaoDivision of Cardiovascular Medicine (J.M.R., M.B., P.R., U.A.T., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0002-5396-4677
Usman A TahirDivision of Cardiovascular Medicine (J.M.R., M.B., P.R., U.A.T., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0002-3657-6082
Julian Avila-PachecoBroad Institute of MIT and Harvard, Cambridge, MA (J.A.-P., C.B.C., R.E.G.).ORCID 0000-0001-9388-3946
Xu ShiCardiovascular Research Center (J.M.R., M.B., G.T., S.D., P.R., U.A.T., X.S., Y.G., F.-G.T., J.L.B., J.G.W., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.t.ORCID 0000-0002-9473-0359
Yuntian GuanCardiovascular Research Center (J.M.R., M.B., G.T., S.D., P.R., U.A.T., X.S., Y.G., F.-G.T., J.L.B., J.G.W., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.t.ORCID 0000-0003-0809-768X
Foje-Geh TendohCardiovascular Research Center (J.M.R., M.B., G.T., S.D., P.R., U.A.T., X.S., Y.G., F.-G.T., J.L.B., J.G.W., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.t.ORCID 0009-0001-7758-9445
Jacob L BarberCardiovascular Research Center (J.M.R., M.B., G.T., S.D., P.R., U.A.T., X.S., Y.G., F.-G.T., J.L.B., J.G.W., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.t.
Patricia E MillerDepartment of Biostatistics, Boston University School of Public Health, MA (P.E.M.).ORCID 0000-0002-0141-717X
Andrew S PerryVanderbilt Translational and Clinical Research Center Cardiology Division, Vanderbilt University Medical Center, Nashville, TN (A.S.P., R.V.S.).ORCID 0000-0003-3342-6158
Michael E HallDepartment of Medicine, University of Mississippi Medical Center, Jackson (M.E.H.).ORCID 0000-0002-5733-1025
Alexis C WoodChildren's Nutrition Research Center, Baylor College of Medicine, Houston, TX (A.C.W.).ORCID 0000-0001-7616-2119
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Torrance, CA (K.D.T., J.I.R.).ORCID 0000-0002-2756-4370
Wendy S PostJohns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (W.S.P.).ORCID 0000-0002-8655-5204
Stephen S RichDepartment of Genome Sciences, University of Virginia, Charlottesville (S.S.R.).ORCID 0000-0003-3872-7793
Matthew NayorSections of Cardiovascular Medicine and Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, MA (M.N.).ORCID 0000-0002-6993-9396
James G WilsonCardiovascular Research Center (J.M.R., M.B., G.T., S.D., P.R., U.A.T., X.S., Y.G., F.-G.T., J.L.B., J.G.W., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.t.ORCID 0009-0002-0283-2970
Gregory D LewisCardiology Division, Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (G.D.L.).ORCID 0000-0001-8108-8240
Ravi V ShahCardiovascular Research Center (J.M.R., M.B., G.T., S.D., P.R., U.A.T., X.S., Y.G., F.-G.T., J.L.B., J.G.W., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.t.ORCID 0000-0002-4471-7156
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Torrance, CA (K.D.T., J.I.R.).ORCID 0000-0001-7191-1723
Scott A SummersDepartment of Nutrition and Integrative Physiology and the Diabetes and Metabolism Center, University of Utah, Salt Lake City (S.A.S.).ORCID 0000-0002-4919-0592
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill (L.M.R.).ORCID 0000-0002-7892-193X
Shingo KajimuraDivision of Endocrinology, Diabetes and Metabolism (A.R.P.V., S.K.), Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0003-0672-5910
Claude BouchardBroad Institute of MIT and Harvard, Cambridge, MA (J.A.-P., C.B.C., R.E.G.).ORCID 0000-0002-0048-491X
Clary B ClishORCID 0000-0001-8259-9245
Mark A SarzynskiDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia (M.A.S.).ORCID 0000-0001-6705-0668
Robert E GersztenDivision of Cardiovascular Medicine (J.M.R., M.B., P.R., U.A.T., R.E.G.), Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0002-6767-7687

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN K. GRINSPOON · 1994 to 2026
$31.6M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
A Biochemical Roadmap of Exercise Signaling - Pilot Project for MoTrPAC ConsortiumU24DK112340 · NIDDK · BROAD INSTITUTE, INC. · PI STEVEN A CARR, Clary B Clish · 2017 to 2026
$16.2M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Metabolomic predictors of insulin resistance and diabetesR01DK081572 · NIDDK · VANDERBILT UNIVERSITY · PI CLISH, CLARY B, GERSZTEN, ROBERT E · 2008 to 2025
$9.3M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201600038CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K08 HL161445NHLBI NIH HHS K23 HL150327NHLBI NIH HHS K23 HL179316NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01 HL047317NHLBI NIH HHS R01 HL047323NHLBI NIH HHS R01 HL047327NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL131029NHLBI NIH HHS U01 HL120393NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK081572NIDDK NIH HHS R01 DK137983NIDDK NIH HHS U24 DK112340NIEHS NIH HHS P30 ES010126NIH HHS R03 OD038387NIMHD NIH HHS HHSN268201800013ININR NIH HHS R01 NR019628
6 · The paper itself

Abstract

backgroundCardiorespiratory fitness is an integrative measure of cardiometabolic health and predictor of survival, yet little is known about its molecular underpinnings. Small molecule metabolites and lipids are increasingly recognized as exercise-stimulated signaling molecules and candidate molecular transducers of cardiorespiratory fitness.

methodsWe performed nontargeted liquid chromatography mass spectrometry-based plasma metabolomics in 654 participants (mean age, 35 years; 55% women) from the HERITAGE Family Study (Health, Risk Factors, Exercise Training, and Genetics) who had cardiorespiratory fitness (maximal oxygen uptake [VO

resultsAn unknown mass spectrometry peak (mass-to-charge, 385.3056; retention time, 3.69 minutes) had the strongest, positive relationship with VO

conclusionsWe identified a novel, lipidated amino acid, N-pal-gln, that is positively associated with VO

Indexed as

Cardiorespiratory FitnessGlutamineAdultAnimalsExercise TestFemaleHumansMaleMetabolomicsMiceMiddle AgedOxygen ConsumptionGlutaminecardiorespiratory fitnessexercisemetabolomicsorganelle biogenesis

Identifiers

PMID41221589
PMCPMC12862896

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.