ArticleFrontiers in medicine2025
Effect of inflammation on neurovascular coupling, microperfusion, and clinical outcomes in ischemic stroke patients: a case series report.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
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9 authors.
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Abstract
Introduction: Ischemic stroke leads to a range of sequelae that affect daily functioning. In many cases, such as wake-up strokes or late hospital arrivals, the therapeutic window for reperfusion is missed for the patient, and functional outcomes remain uncertain. The inflammatory response to ischemia plays a pivotal role in the initiation, progression, and recovery phase of stroke. Yet, a gap remains in understanding its impact on neuroimaging and clinical outcomes. This prospective case series investigates the relationship between inflammation, neuroimaging findings in the first 48 h after stroke onset, and 6-months clinical outcomes. Methods: Biomarkers of inflammation, such as C-reactive protein ( Results: A total of 23 wake-up stroke patients not eligible for reperfusion therapy were included: 11 with cortical ischemic lesions and 12 with subcortical or deep ischemic lesions, involving the thalamus, basal ganglia, brainstem, or cerebellum. Significant differences were observed in pseudodiffusion ( Discussion: These preliminary findings suggest that combining inflammatory and neuroimaging markers across cortical and subcortical stroke subtypes could enhance understanding of inflammation's role in early hemodynamic responses and long-term effects outcomes. Further research is needed to explore the broader implications of these case series representations.
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