Evidence map›Paper›PMID 41221501›Full record

ArticleBiophysics reports2025

Preparation of mechano-nanoswitches for ultrasound-controlled drug activation.

Zhihuan Liao, Junliang Chen, Menghan Xiao, Shuaidong Huo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Size-Dependent Ultrasound Activation of Thrombin Catalytic Activity by Mechano-Nanoswitches.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhihuan Liao *Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, Fujian, China.
Junliang Chen *Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, Fujian, China.
Menghan XiaoFujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, Fujian, China.
Shuaidong HuoFujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy is often hindered by issues associated with deficient drug selectivity and ineluctable toxic effects. The emerging realm of mechanochemistry has demonstrated significant promise in precise drug activation by using ultrasound-induced mechanical forces to regulate the chemical properties of compounds at the molecular level. Recently, we proved that the successful introduction of nanostructures to mechanochemistry could improve drug loading capacity and enhance their mechanical responsiveness. To further expand the application of the ultrasound-response drug activation strategy in nanosystems, in this context, we illustrate the preparation of a mechano-nanoswitch for spatiotemporal control of drug activation.

Indexed as

Drug activationForce-sensitiveMechano-nanoswitchNanodimerUltrasound

Identifiers

PMID41221501
PMCPMC12602112

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.