ArticleDrug design, development and therapy2025
The Gastroprotective Effect of Hydrogen-Rich Coral Calcium in a Mouse Model of Peptic Ulcer Disease.
Article in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Comparative Efficacy of Coral Calcium Carried Hydrogen versus Dexamethasone in a Mouse Model of Allergic Contact Dermatitis.Journal of inflammation research · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Peptic ulcer disease (PUD), including gastric and duodenal ulcers, is primarily caused by Methods: The gastroprotective effects of HRCC were investigated in a mouse model of PUD, and macroscopic score was used to investigate the effects of HRCC on PUD. In addition, the expression of the pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), C-C motif chemokine ligand 2 (Ccl2), and interleukin-6 (IL-6) by real-time quantitative polymerase chain reaction. In addition, Western blots were used to evaluate the expressions of anti-oxidative enzymes, including catalase, glutathione peroxidase-1 (GPx), and superoxide dismutase (SOD). Results: HRCC attenuated ulcer severity induced by ethanol and hydrogen chloride ex vivo (n = 6). In addition, long-term treatment of HRCC for seven-day reduced ethanol and hydrogen chloride-induced ulcer formation (n = 6). Moreover, we found that HRCC treatment decreased immune cell infiltration, the gene expressions of pro-inflammatory cytokines (n = 6), and enhanced antioxidative enzyme levels (n = 3) in stomach of the animals in vivo. Conclusion: HRCC has potential as a gastroprotective agent with anti-oxidative and anti-inflammatory activities, and its application may provide an alternative for treating PUD.
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Registered trials
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