ReviewMedicine and pharmacy reports2025
Surgical resection for multiple brain metastases: a systematic review and meta-analysis of functional and survival outcomes.
Review in Medicine and pharmacy reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Brain metastases (BMs) are the most common intracranial tumors among adults, which exceed primary brain tumors by far. Surgery and radiotherapy represent the key local management of BM. However, the exact role of surgery is still under debate. Objective: To comprehensively evaluate the safety and efficacy of surgical management in patients with brain metastases. Methods: We searched four electronic databases from January 2023 until September 2024 (PubMed, Scopus, Web of Science, and Cochrane Library). All the studies assessing the role of surgery in managing BM were included. Our primary search targets were survival, mortality, and postoperative Karnofsky Performance Status (KPS). The results were reported as pooled mean or proportions with 95% confidence interval (CI) for continuous and dichotomous data, respectively. Results: Eight observational studies comprising 1010 patients met our inclusion criteria. The pooled mean of overall survival was 10.482 with 95% CI [7.651, 13.314]. While the pooled proportion of one-year and two-year survival was (0.451, 95% CI [0.320, 0.582]) and (0.240, 95% CI [0.112, 0.367]), respectively. We found the pooled proportion of overall mortality to be 0.535 with 95% CI [0.278, 0.793]. Patients with immediate postoperative KPS improvement showed a pooled estimate of 0.463 with 95% CI [0.243, 0.683]. Conclusion: Surgical resection is an effective therapeutic option for patients with BMs. Yet, careful patient selection and surgical technique are crucial for reducing postoperative complications and death.
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