ReviewHealth science reports2025
B-Type Natriuretic Peptides Levels in Patients With Beta-Thalassemia Major and Correlations With Biomarkers: A Systematic Review and Meta-Analysis.
Review in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Patients with beta-thalassemia major are prone for developing cardiovascular complications. Early identification of patients at risk is important. B-type natriuretic peptides such as brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) are sensitive indicators of cardiac dysfunction. This review synthesizes the existing evidence on the levels of B-type natriuretic peptides in beta-thalassemia major and their relationship with markers of cardiac dysfunction and other biomarkers. Methods: A systematic review was conducted according to PRISMA guidelines. The search was performed in the PubMed, Web of Science, ScienceDirect, and World Health Organization Virtual Health Library Regional Portal. Pooled standardized mean differences (SMD) and correlation coefficients ( Results: A total of 29 studies were selected for the systematic review. Of them, 27 were included in the meta-analyses. Most of the included studies focused on investigating NT-proBNP. The analyses revealed significantly higher NT-proBNP and BNP values in patients with beta-thalassemia major compared to healthy controls. For NT-proBNP, the pooled effect size (SMD) was 1.37 (95% CI: 0.856-1.893, Conclusion: This systematic review provides evidence that beta-thalassemia is associated with high levels of B-type natriuretic peptides, which highlight the high risk of cardiovascular complications in this patient population. The significantly elevated levels of both molecules and their identified correlations emphasize clinical utility of them as markers of early myocardial stress and subclinical heart disease in beta-thalassemia.
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Registered trials
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