Evidence map›Paper›PMID 41221409›Full record

ReviewCureus2025

Effect of Environmental Factors on Bone Remodelling: A Narrative Review.

Bawan Hama, Shahan Hama, Abdulrahman Kashkosh, Fadel Jesry, Isbah Munir, Maha Ejaz, Hassan Kazemi

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bawan HamaTrauma and Orthopaedics, King's College Hospital NHS Foundation Trust, London, GBR.
Shahan HamaTrauma and Orthopaedics, Royal Devon University Healthcare NHS Foundation Trust, Exeter, GBR.
Abdulrahman KashkoshTrauma and Orthopaedics, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, GBR.
Fadel JesryTrauma and Orthopaedics, Mid Yorkshire Teaching NHS Trust, Wakefield, GBR.
Isbah MunirTrauma and Orthopaedics, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, GBR.
Maha EjazPlastic Surgery, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, GBR.
Hassan KazemiTrauma and Orthopaedics, Bolton NHS Foundation Trust, Bolton, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone remodelling is a finely balanced process primarily maintained by two fundamental cell types: osteoblasts and osteoclasts. Many intrinsic and extrinsic factors can affect this process leading to pathological conditions such as osteoporosis. This narrative review focuses on some of the key environmental factors affecting bone remodelling including physical activity, lifestyle factors, nutrition, pollution, medications, and environmental stressors. We will attempt to identify some of the key pathways affected, and how this impacts bone health, whilst using this knowledge to look at possible therapeutic options.

Indexed as

bisphosphonate usebone healthbone remodellingenvironmental factorsosteoblastosteoclastosteoporosisphysical activitysmoking

Identifiers

PMID41221409
PMCPMC12599577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.