ArticleVascular health and risk management2025
Correlation Between Activity Level of Renin-Angiotensin-Aldosterone System and Perfusion Index in Children with Postural Tachycardia Syndrome.
Article in Vascular health and risk management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Correlation Between Activity Level of Renin-Angiotensin-Aldosterone System and Perfusion Index in Children with Postural Tachycardia Syndrome.Vascular health and risk management · 2025Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the relationship between Renin-Angiotensin-Aldosterone System (RAAS) activity and Perfusion Index (PI) in children with Postural Tachycardia Syndrome (POTS), and to assess the diagnostic performance of Angiotensin II (AngII) and PI for POTS status. Methods: A total of 65 children with POTS and 65 age- and sex-matched healthy controls were enrolled. Plasma renin, angiotensin I (AngI), AngII, and aldosterone were quantified via enzyme-linked immunosorbent assay, and PI was measured using a pulse oximetry-based monitor during head-up tilt testing. Statistical analyses included Receiver Operating Characteristic (ROC) curve analysis of AngII and PI for POTS status, binary logistic regression, and Pearson correlation. Results: Compared to controls, children with POTS demonstrated a significantly lower PI (4.64 ± 1.54 vs 6.19 ± 1.64%; adjusted Conclusions: PI is a valuable, noninvasive clinical marker for POTS in children, demonstrating superior diagnostic utility compared to AngII. While elevated AngII retains clinical significance by reflecting underlying pathophysiology and disease severity, its independent predictive value is limited. The combined assessment of PI and AngII may enhance the pathophysiological understanding and management strategies for pediatric POTS.
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