Evidence map›Paper›PMID 41221326›Full record

ReviewJournal of oral microbiology2025

Potential roles and mechanisms of bacterial peptidylarginine deiminase in dental biofilm mediated by

Yitong Chen, Jiale Lou, Ying Fang, Shibo Ying

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of oral microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Tregs and persistentFrontiers in oral health · 2026
    Article
  2. Journal of oral microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yitong ChenSavaid Stomatology School, Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
Jiale LouSavaid Stomatology School, Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
Ying FangSavaid Stomatology School, Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.
Shibo YingSavaid Stomatology School, Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.ORCID https://orcid.org/0000-0001-5275-9383

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Objective: This review aims to synthesize current knowledge on PPAD, with a specific focus on its mechanistic roles in oral biofilm dynamics and its potential contribution to the development of periodontitis and rheumatoid arthritis (RA). Design: A comprehensive literature search was conducted using the PubMed database up to August 2025, employing keywords including 'PPAD', ' Results: PPAD contributes critically to biofilm pathogenicity by modulating microbial pH, citrullinating virulence factors, and facilitating polymicrobial interactions. It promotes bacterial adhesion, disrupts host immunity, and sustains local inflammation. Systemically, PPAD-generated citrullinated antigens may trigger autoimmune responses, potentially linking periodontitis to RA. Conclusion: PPAD represents a promising biomarker and therapeutic target for mitigating oral-systemic disease progression. Future research should prioritize elucidating its spatiotemporal regulation within biofilms and its immune-dysregulating effects to guide precision interventions.

Indexed as

citrullinationdental biofilmperiodontitisPorphyromonas gingivalisporphyromonas peptidylarginine deiminase (PPAD)

Identifiers

PMID41221326
PMCPMC12599369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.