Evidence map›Paper›PMID 41221301›Full record

ArticleNeuroImmune pharmacology and therapeutics2025

Sex differences in the capacity of minor phytocannabinoids to attenuate nociceptive insults in HIV-1 Tat-expressing mice.

Alaa N Qrareya, Emaya Moss, Fakhri Mahdi, Mohammad F Salahuddin, Duoyi Hu, Miguel A De Leon, Amira S Wanas, Mohamed M Radwan, Mahmoud A ElSohly, Nicole M Ashpole and 1 more

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In one paragraph

Article in NeuroImmune pharmacology and therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alaa N QrareyaDepartment of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
Emaya MossDepartment of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
Fakhri MahdiDepartment of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
Mohammad F SalahuddinDepartment of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
Duoyi HuDepartment of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
Miguel A De LeonDepartment of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
Amira S WanasNational Center for Natural Products Research, University of Mississippi, University, MS, 38677, USA.
Mohamed M RadwanNational Center for Natural Products Research, University of Mississippi, University, MS, 38677, USA.
Mahmoud A ElSohlyNational Center for Natural Products Research, University of Mississippi, University, MS, 38677, USA.
Nicole M AshpoleDepartment of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.
Jason J ParisDepartment of BioMolecular Sciences, University of Mississippi, University, MS, 38677, USA.ORCID https://orcid.org/0000-0002-5628-1134

Funding

Anti-inflammatory Effects of Novel Minor Cannabinoids and Terpenes on Cellular and Murine Models of HIV and HIV ProteinsR01DA052851 · NIDA · UNIVERSITY OF MISSISSIPPI · PI ASHPOLE, NICOLE M, PARIS, JASON RICHARD · 2020 to 2023
$1.4M
NIDA NIH HHS R01 DA052851
6 · The paper itself

Abstract

Objecives: Approximately 80 % of people living with HIV (PLWH) develop chronic pain and preclinical studies support the involvement of the HIV-1 regulatory protein, trans-activator of transcription (Tat). Phytocannabinoids may attenuate pain in PLWH; however, these data are controversial, and the biological mechanisms are difficult to untangle from psychosocial factors in people. Methods: We have examined the therapeutic capacity of minor phytocannabinoids to attenuate Tat-promoted visceral hyperalgesia (acetic acid writhing assay) and reflexive nociception (warm water tail flick assay) in transgenic mice. We hypothesized that conditional expression of Tat Results: Irrespective of sex, Tat(+) mice demonstrated greater visceral pain responses than did Tat(-) controls. The phytocannabinoids, cannabigerolic acid (CBGA), cannabidiol (CBD), and cannabinol (CBN), attenuated Tat-induced visceral pain in both males and females. However, the effectiveness of these cannabinoids varied by sex with CBN being more efficacious in males, while cannabigerol (CBG) alleviated visceral pain only in Tat(+) females. Cannabidiolic acid (CBDA) and cannabidivarin (CBDV) were not effective in either sex. CBGA and CBG were also efficacious in the tail flick test among Tat(-) males and females, but demonstrated only small, sex-dependent effects to reverse Tat-induced nociception. CBD and CBN exerted little-to-no efficacy in this test. Conclusions: These data suggest that phytocannabinoids exert analgesia for HIV-related pain, potentially aiding in the development of personalized pain management strategies.

Indexed as

behavioral pharmacologycannabinoidspainsex differencestrans-activating transcriptor

Identifiers

PMID41221301
PMCPMC12601221

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