Evidence map›Paper›PMID 41221279›Full record

ReviewFrontiers in immunology2025

Case Report: IgG4-related ophthalmic disease presenting with unilateral proptosis.

Xiaodong Li, Xuewei Qin, Mei Chen, Xi Zheng

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaodong LiThe First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Ophthalmology, Guiyang, China.
Xuewei QinThe First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Ophthalmology, Guiyang, China.
Mei ChenThe First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Ophthalmology, Guiyang, China.
Xi ZhengTraditional Chinese Medicine Hospital of Meishan, Ophthalmology, Meishan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IgG4-related eye disease (IgG4-ROD) is characterized by diffuse swelling or well-defined masses in the lacrimal glands, extraocular muscles, and eyelids, often accompanied by eyelid swelling, proptosis, and diplopia. It typically affects both sides symmetrically and can mimic various infectious, inflammatory, and neoplastic diseases. Early recognition and steroid therapy can significantly improve symptoms, but recurrence is common, necessitating careful and long-term follow-up. B-cell depletion therapy, such as rituximab, is increasingly being incorporated into standard treatment protocols. This article reports a case of IgG4-ROD misdiagnosed as a unilateral orbital mass, summarizing its clinical features, diagnostic approach, and treatment outcomes. Combined with a literature review and analysis, this study aims to provide reference for the clinical identification of IgG4-ROD.

Indexed as

ExophthalmosEye DiseasesImmunoglobulin GImmunoglobulin G4-Related DiseaseDiagnosis, DifferentialFemaleHumansMaleMiddle AgedRituximabImmunoglobulin GRituximabcase reportglucocorticoidsIgG4-related eye diseaseIgG4-RODunilateral orbital mass

Identifiers

PMID41221279
PMCPMC12597921

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.