ArticleFrontiers in veterinary science2025
Phylogenetic analysis and biological characteristics of an Akabane virus isolated in China.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Akabane virus (AKAV) is an arbovirus that can cause miscarriage, premature birth, congenital malformations, and encephalomyelitis in young livestock. It is currently widely prevalent in China. Vero and MDBK cells were utilized to determine the virus titer and growth curve of the AKAV FS202301 strain in this study. Subsequently, the viral solution was intracranially (IC) or intraperitoneally (IP) inoculated into 8-day-old suckling mice, and the pathogenicity was explored by observing clinicopathological changes, and hematoxylin-eosin (HE) staining. Additionally, the S, M, and L segment sequences of the FS202301 strain were analyzed, phylogenetic trees were constructed, and antigenic epitopes were predicted to investigate its genetic variation. The results revealed that the viral titer of strain FS202301 was 10
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