Evidence map›Paper›PMID 41221112›Full record

ArticleChemical science2026

Imaging intracellular zinc by stimulated Raman scattering microscopy with a small molecule vibrational probe.

Elsy El Khoury, Symara de Melo Silva, Naixin Qian, Vinh Gia Vuong, Wei Min, Daniela Buccella

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elsy El KhouryDepartment of Chemistry, New York University New York NY 10003 USA daniela.buccella@emory.edu.ORCID https://orcid.org/0000-0002-9414-7032
Symara de Melo SilvaDepartment of Chemistry, New York University New York NY 10003 USA daniela.buccella@emory.edu.ORCID https://orcid.org/0009-0008-7403-383X
Naixin QianDepartment of Chemistry, Columbia University New York NY 10027 USA wm2256@columbia.edu.
Vinh Gia VuongDepartment of Chemistry, New York University New York NY 10003 USA daniela.buccella@emory.edu.
Wei MinDepartment of Chemistry, Columbia University New York NY 10027 USA wm2256@columbia.edu.ORCID https://orcid.org/0000-0003-2570-3557
Daniela BuccellaDepartment of Chemistry, New York University New York NY 10003 USA daniela.buccella@emory.edu.ORCID https://orcid.org/0000-0002-2266-9026

Funding

Super-multiplex optical imaging: development of novel spectroscopy and probes to illuminate complex biomedicineR35GM149256 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Wei Min · 2023 to 2026
$2.8M
Super-Multiplexed Molecular Sensing in Live CellsR01GM151093 · NIGMS · NEW YORK UNIVERSITY · PI Daniela Buccella · 2023 to 2026
$1.0M
NIGMS NIH HHS R01 GM151093NIGMS NIH HHS R35 GM149256
6 · The paper itself

Abstract

Advanced Raman-based techniques, particularly stimulated Raman scattering (SRS) microscopy, have emerged as valuable bioimaging tools. But advances in the development of the chemical toolbox required for detection of biologically relevant species, including metals, has lagged the rapid advances in instrumentation. To date, few responsive probes for dynamic detection of transient and low abundance species have been developed. We describe herein the design and application of CSZin, a small molecule vibrational probe for detection of Zn

Identifiers

PMID41221112
PMCPMC12599042

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.