Evidence map›Paper›PMID 41221082›Full record

ArticleEuropean heart journal open2025

Secondary hyperparathyroidism in adult congenital heart disease: the CHD-HYPER-study.

Friederike Löffler, Justus Christian Garlichs, Kirsten Linhorst, Ann-Sophie Silber-Peest, Sabrina Uehlein, Holger Leitolf, Christoph Terkamp, Katja Deterding, Johann Bauersachs, Mechthild Westhoff-Bleck

Abstract read
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. First quinquennium completed: highlights fromEuropean heart journal open · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Friederike LöfflerDepartment of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany.ORCID https://orcid.org/0009-0009-1999-3480
Justus Christian GarlichsDepartment of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany.
Kirsten LinhorstDepartment of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany.
Ann-Sophie Silber-PeestDepartment of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany.
Sabrina UehleinDepartment of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany.
Holger LeitolfDepartment of Gastroenterology, Hepatology, Infectiology and Endocrinology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany.
Christoph TerkampDepartment of Gastroenterology, Hepatology, Infectiology and Endocrinology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany.
Katja DeterdingDepartment of Gastroenterology, Hepatology, Infectiology and Endocrinology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany.
Johann BauersachsDepartment of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany.ORCID https://orcid.org/0000-0002-9341-117X
Mechthild Westhoff-BleckDepartment of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: In non-congenital heart disease, secondary hyperparathyroidism (sHPT) is associated with an elevated risk of new-onset heart failure (HF) and an increased incidence of HF-related hospitalizations. Yet, for adults with congenital heart disease (ACHD), the role of sHPT and the factors contributing to its development remain poorly understood. Methods and results: This cross-sectional, single-centre study assessed the prevalence of sHPT in 754 patients with ACHD. Independent predictors of sHPT were identified in both, within the entire cohort and specifically in ACHD with biventricular physiology. Findings: We found a high prevalence of sHPT in ACHD at 14.9%, with the highest rates in patients with Eisenmenger syndrome/PAH-CHD (39.1%), Ebstein's anomaly (29.2%), Fontan palliation (25%), and pulmonary atresia (25%). SHPT was more common in patients with univentricular physiology (29.6%) than biventricular physiology (13.3%) ( Conclusion: sHPT is observed across the spectrum of ACHD but is more common in patients with complex and more severe disease, particularly those with predominant right heart involvement.

Indexed as

Adult congenital heart diseaseHeart failureHyperparathyroidismParathyroid hormoneRight heart diseaseVitamin D deficiency

Identifiers

PMID41221082
PMCPMC12598750

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.