Evidence map›Paper›PMID 41221055›Full record

ArticleFrontiers in pharmacology2025

Synthetic bakuchiol derivatives: ester and ether analogs with activity against clinically important bacteria.

Francisca Valdés, Evelyn Muñoz, Manuel Martinez, Catalina Ferreira, Valentina Silva, Alejandro Madrid, Katy Díaz, Constanza Villarroel, Iván Montenegro

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francisca ValdésLaboratory of Natural Products and Organic Synthesis (LPNSO), Department of Science and Geography, Faculty of Natural and Exact Sciences, Universidad de Playa Ancha, Valparaíso, Chile.
Evelyn MuñozLaboratory of Natural Products and Organic Synthesis (LPNSO), Department of Science and Geography, Faculty of Natural and Exact Sciences, Universidad de Playa Ancha, Valparaíso, Chile.
Manuel MartinezLaboratory of Natural Products and Organic Synthesis (LPNSO), Department of Science and Geography, Faculty of Natural and Exact Sciences, Universidad de Playa Ancha, Valparaíso, Chile.
Catalina FerreiraLaboratory of Natural Products and Organic Synthesis (LPNSO), Department of Science and Geography, Faculty of Natural and Exact Sciences, Universidad de Playa Ancha, Valparaíso, Chile.
Valentina SilvaLaboratory of Natural Products and Organic Synthesis (LPNSO), Department of Science and Geography, Faculty of Natural and Exact Sciences, Universidad de Playa Ancha, Valparaíso, Chile.
Alejandro Madrid *Laboratory of Natural Products and Organic Synthesis (LPNSO), Department of Science and Geography, Faculty of Natural and Exact Sciences, Universidad de Playa Ancha, Valparaíso, Chile.
Katy DíazDepartment of Chemistry, Universidad Técnica Federico Santa María, Valparaíso, Chile.
Constanza VillarroelMillennium Nucleus Bioproducts, Genomics and Environmental Microbiology (BioGEM), Valparaíso, Chile.
Iván Montenegro *Millennium Nucleus Bioproducts, Genomics and Environmental Microbiology (BioGEM), Valparaíso, Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: With the rise of antibiotic resistance and healthcare-associated infections, there is a growing need for alternative therapies. Methods: From the aerial parts of Results: The ester derivatives exhibited bactericidal activity against Conclusion: These results support the potential of bakuchiol ester-type derivatives as antibacterial agents, which encourages future

Indexed as

antibacterial activitybakuchiolbakuchiol derivativesclinical bacteriaOtholobium glandulosum

Identifiers

PMID41221055
PMCPMC12597907

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.