SynthesisFrontiers in pharmacology2025
Stereotactic body radiotherapy (SBRT) in oligometastatic ovarian cancer (OMOC): a systematic review and meta-analysis of clinical outcomes and toxicity profiles.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Orbital Metastases of Breast Cancer: Case Report and Review of the Literature.Oncology research · 2026Review
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Abstract
Introduction: Oligometastatic ovarian cancer (OMOC) represents a distinct clinical state with a limited metastatic burden, potentially amenable to local ablative strategies. Stereotactic body radiotherapy (SBRT) has emerged as a promising treatment in this context, offering high-dose precision with minimal toxicity. However, evidence of its role in OMOC remains fragmented. Methods: We conducted a systematic review and meta-analysis of studies evaluating SBRT in patients with OMOC, focusing on clinical outcomes, including local control (LC), progression-free survival (PFS), overall survival (OS), and grade ≥3 toxicities. Eligible studies were identified through a comprehensive search across PubMed, Embase, Scopus, and Cochrane Library up to March 2025. Data synthesis involved pooled analysis using random-effects models. Results: Eight retrospective or prospective studies, encompassing 594 patients, were included. The majority of patients had received at least two prior lines of therapy. SBRT was delivered to ≤5 lesions, commonly during systemic treatment-free intervals or maintenance with PARP inhibitors. One-year LC ranged from 86.7% to 94.4%, and 2-year LC ranged from 60.9% to 88.9%. Median PFS ranged from 7.4 to 15.0 months, and median OS from 21.0 to 43.0 months. Grade ≥3 toxicities were rare (0%-6.1%), and no treatment-related deaths were reported. Discussion: SBRT demonstrates favorable LC and survival outcomes in selected OMOC patients while maintaining a low toxicity profile, despite current evidence being descriptive and thus to be interpreted with caution. SBRT use during systemic treatment breaks or as a tool to control oligoprogressive disease under maintenance therapy suggests a potential role in extending treatment-free intervals. These findings support SBRT as a valuable component of a multidisciplinary approach to OMOC and underscore the need for prospective, context-specific trials to validate these results. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251161822, identifer CRD420251161822.
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