ArticleFrontiers in pharmacology2025
Effects of different opioids on the contractile tension of isolated rat intestinal smooth muscle.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Backgroud: To compare how five common opioids affect rat intestinal muscle tension and frequency across concentrations, establishing an animal model to provide translational evidence for selecting opioids with the least gastrointestinal impact. Methods: Isolated rat small intestine specimens were prepared, and six intestinal segments were selected from the same rat and placed into remifentanil, sufentanil, oxycodone, nalbuphine, butorphanol, and the control group with balanced solution. Experiments were carried out to observe and compare the changes in the contraction tension and contraction frequency of small intestinal smooth muscle during the change in concentration gradients of 10- Results: The results revealed that when the concentration increased to 10 Conclusion: As the concentration increased, different opioids inhibited the contractile tone of rat intestinal smooth muscle
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